Double filtration blood purification apparatus and method of priming therefor

Abstract

To provide a double filtration blood purification apparatus that can be primed while generation of bubbles within each of a separating membrane in both of a blood component separator and a plasma component separator is avoided and also to provide a method of priming such blood purification apparatus. A cleansing liquid introducing passage 19 is provided, which is a passage dedicated to introduce a cleansing liquid P from a cleansing liquid supply source 57 into a plasma component separator 3 and, also, this cleansing liquid introducing passage 19 is provided with a dedicated, third pump 3. When the third and first pumps are driven in normal and reverse directions, respectively, by a controller 50, a sufficient pressure is applied to the cleansing liquid P by the third ump and the cleansing liquid P can be introduced into the plasma component separator 3.

Description

[0001] This application claims the priority of Japanese Patent Application No. 2007-156638 for which it applied on June 13, 2007, and takes in the whole content as a part of this application. technical field [0002] The present invention relates to a double filter blood purification device having a blood component separator for separating plasma components from blood, and a device for removing high molecular weight components from the separated plasma components, and a priming method thereof. Plasma component separator. Background technique [0003] As a device for treating hepatic insufficiency, autoimmune diseases, etc., there is known a double-filter blood purification device that uses a blood component separator to separate blood into blood cell components and plasma components, and uses a plasma component separator to separate The extracted plasma components are separated into low molecular weight components and high molecular weight components containing toxins. This...

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Problems solved by technology

[0008] However, in the priming method of the above-mentioned Patent Document 1, when the cleaning liquid is made to flow to the plasma component separator, the air in the circuit may be mixed into the separation membrane of the plasma component separator, but the plasma component will be introduced through the plasma channel. The above-mentioned discharge pump that discharges the cleaning liquid of the separator to the outside of the system also has the function of directly introducing the cleaning liquid from the cleaning liquid supply source to the outside of the separation membrane of the plasma component separator, so the cleaning liquid introduced to the outside of the separation membrane cannot be sufficiently Pressurize to an extent sufficient to drive out air mixed in the separation membrane

As a result, the area of ​​the separation membrane decreases due to the presence of air, so the separation performance of the plasma component separator decreases

[0009] In addition, in the priming method of the above-mentioned Patent Document 2, since the plasma separation pump is reversed to draw the cleaning liquid from the return plasma circuit to the plasma separation circuit through the plasma component separator, the path of the cleaning liquid becomes longer, so the plasma The pressure in the component separator, the return plasma circuit, and the plasma separation circuit tends to drop, that is, negative pressure is likely to be generated. etc., air bubbles are generated in each circuit and the separation membrane of the plasma component separator, or the above-mentioned separation membrane is damaged, so there is a possibility that the separation ability of the plasma component separator decreases and the performance of the blood purification device as a whole decreases.

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