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Coenzyme Q-10/EGF liposome, preparation method and application

A liposome and coenzyme technology, which is applied in the fields of pharmaceutical preparations, cosmetics, and skin care products, can solve problems such as particle aggregation, drug leakage, and liposome instability, and achieve simple preparation methods, anti-aging skin repair, and reduced system stable effect

Active Publication Date: 2012-12-05
GUANGDONG MARUBI BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for different target drugs, it is necessary to select a suitable lipid material and molding process to obtain a satisfactory liposome-encapsulated drug, otherwise liposome instability, drug leakage or particle aggregation will easily occur.
[0008] At present, there is no relevant research report on the combination of coenzyme Q-10 and EGF for the preparation of cosmetics and skin care products, and there is no combination of liposome encapsulation technology, coenzyme Q-10 and EGF for cosmetics and skin care products. Prepared related research reports

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The coenzyme Q-10 / EGF liposome of the present embodiment is made up of the following components in parts by weight:

[0035] Coenzyme Q-10 2.5 parts;

[0036] EGF 7.5 parts;

[0037] Cholesterol 10 parts;

[0038] Lecithin 80 parts;

[0039] The average particle diameter of the coenzyme Q-10 / EGF liposome is 150-200 nm.

[0040] The above-mentioned cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are all commercially available pure products.

[0041] The preparation method of the present embodiment coenzyme Q-10 / EGF liposome, its specific steps are as follows:

[0042] Cholesterol, lecithin, coenzyme Q-10 and EGF are added into an organic solvent and fully dissolved to obtain a mixed solution. The mixed solution is passed through nitrogen while rotating to evaporate the organic solvent to obtain a nanoemulsion, and then ice water is added to the nanoemulsion to obtain a nanoemulsion. Aqueous suspension, and finally obtain the required coenzyme Q-10 / EGF liposo...

Embodiment 2

[0045] The coenzyme Q-10 / EGF liposome of the present embodiment is made up of the following components in parts by weight:

[0046] Coenzyme Q-10 5 parts;

[0047] EGF 4.5 parts;

[0048] Cholesterol 25 parts;

[0049] Lecithin 65 parts;

[0050] Vitamin E 0.5 parts.

[0051] The average particle diameter of the coenzyme Q-10 / EGF liposome is 150-200 nm.

[0052] The above-mentioned cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are all commercially available pure products.

[0053] The preparation method of the present embodiment coenzyme Q-10 / EGF liposome, its specific steps are as follows:

[0054] Cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are added into an organic solvent and fully dissolved to obtain a mixed solution. The mixed solution is passed through nitrogen while rotating to evaporate the organic solvent to obtain a nanoemulsion, and then add ice to the nanoemulsion. Sonicate water to obtain an aqueous suspension, and finally obtain the d...

Embodiment 3

[0057] The coenzyme Q-10 / EGF liposome of the present embodiment is made up of the following components in parts by weight:

[0058] Coenzyme Q-10 5.5 parts;

[0059] EGF 6.3 parts;

[0060] Cholesterol 30 parts;

[0061] Lecithin 58 parts;

[0062] Vitamin E 0.2 parts.

[0063] The average particle diameter of the coenzyme Q-10 / EGF liposome is 150-200 nm.

[0064] The above-mentioned cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are all commercially available pure products.

[0065] The preparation method of the present embodiment coenzyme Q-10 / EGF liposome, its specific steps are as follows:

[0066] Cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are added into an organic solvent and fully dissolved to obtain a mixed solution. The mixed solution is passed through nitrogen while rotating to evaporate the organic solvent to obtain a nanoemulsion, and then add ice to the nanoemulsion. Sonicate water to obtain an aqueous suspension, and finally obtain the...

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Abstract

The invention discloses coenzyme Q-10 / EGF liposome, a preparation method and application. The coenzyme Q-10 / EGF liposome consists of the following components in part by weight: 2.5 to 6 parts of coenzyme Q-10, 3 to 7.5 parts of epidermal growth factor (EGF), 10 to 30 parts of cholesterol, 50 to 80 parts of lecithin and 0 to 0.5 part of vitamin E. According to the coenzyme Q-10 / EGF liposome, phospholipid bi-layer is used as a carrier material, the coenzyme Q-10 and the EGF can automatically coated in the phospholipid bi-layer, so that excipient and plasticizer are avoided; the preparation method is simple; and the coenzyme Q-10 and the EGF have good stability. The coenzyme Q-10 / EGF liposome has remarkable effects of skin aging resistance and repair, and does not destroy the system stability of cosmetics or health-care products when used in the cosmetics or the health-care products; and due to the structure of the liposome, the coenzyme Q-10 and the EGF can be better absorbed by the skin.

Description

technical field [0001] The invention relates to the fields of pharmaceutical preparations, cosmetics and skin care products, in particular to the application of the combination of coenzyme Q-10, EGF and liposome encapsulation technology in cosmetics and skin care products. Background technique [0002] With the gradual aging of our society, anti-aging beauty and skin care are getting more and more attention. [0003] Coenzyme Q-10 is a very small amount of substances necessary for life activities that are ubiquitous in human and animal organs and tissues. Coenzyme Q-10 has anti-aging, cardiovascular disease prevention, anti-tumor, immune regulation, anti-skin wrinkle and The efficacy of delaying skin aging and other aspects has been confirmed. [0004] EGF (Epidermal Growth Factor) is an active substance in the human body. It is a living cell composed of 53 amino groups. It has a significant effect on shrinking pores and anti-wrinkle. The reason is that EGF can promote the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/64A61K8/35A61K8/14A61Q19/08
Inventor 方永生
Owner GUANGDONG MARUBI BIOLOGICAL TECH CO LTD
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