Coenzyme Q-10/EGF liposome, preparation method and application
A liposome and coenzyme technology, applied in the fields of skin care products, pharmaceutical preparations and cosmetics, can solve the problems of particle aggregation, drug leakage, liposome instability, etc., and achieves a simple preparation method, anti-aging skin repair, reducing system stable effect
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Embodiment 1
[0034] The coenzyme Q-10 / EGF liposome of the present embodiment is made up of the following components in parts by weight:
[0035] Coenzyme Q-10 2.5 parts;
[0036] EGF 7.5 parts;
[0037] Cholesterol 10 parts;
[0038] Lecithin 80 parts;
[0039] The average particle diameter of the coenzyme Q-10 / EGF liposome is 150-200 nm.
[0040] The above-mentioned cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are all commercially available pure products.
[0041] The preparation method of the present embodiment coenzyme Q-10 / EGF liposome, its specific steps are as follows:
[0042] Cholesterol, lecithin, coenzyme Q-10 and EGF are added into an organic solvent and fully dissolved to obtain a mixed solution. The mixed solution is passed through nitrogen while rotating to evaporate the organic solvent to obtain a nanoemulsion, and then ice water is added to the nanoemulsion to obtain a nanoemulsion. Aqueous suspension, and finally obtain the required coenzyme Q-10 / EGF liposo...
Embodiment 2
[0045] The coenzyme Q-10 / EGF liposome of the present embodiment is made up of the following components in parts by weight:
[0046] Coenzyme Q-10 5 parts;
[0047] EGF 4.5 parts;
[0048] Cholesterol 25 parts;
[0049] Lecithin 65 parts;
[0050] Vitamin E 0.5 parts.
[0051] The average particle diameter of the coenzyme Q-10 / EGF liposome is 150-200 nm.
[0052] The above-mentioned cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are all commercially available pure products.
[0053] The preparation method of the present embodiment coenzyme Q-10 / EGF liposome, its specific steps are as follows:
[0054] Cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are added into an organic solvent and fully dissolved to obtain a mixed solution. The mixed solution is passed through nitrogen while rotating to evaporate the organic solvent to obtain a nanoemulsion, and then add ice to the nanoemulsion. Sonicate water to obtain an aqueous suspension, and finally obtain the d...
Embodiment 3
[0057] The coenzyme Q-10 / EGF liposome of the present embodiment is made up of the following components in parts by weight:
[0058] Coenzyme Q-10 5.5 parts;
[0059] EGF 6.3 parts;
[0060] Cholesterol 30 parts;
[0061] Lecithin 58 parts;
[0062] Vitamin E 0.2 parts.
[0063] The average particle diameter of the coenzyme Q-10 / EGF liposome is 150-200 nm.
[0064] The above-mentioned cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are all commercially available pure products.
[0065] The preparation method of the present embodiment coenzyme Q-10 / EGF liposome, its specific steps are as follows:
[0066] Cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are added into an organic solvent and fully dissolved to obtain a mixed solution. The mixed solution is passed through nitrogen while rotating to evaporate the organic solvent to obtain a nanoemulsion, and then add ice to the nanoemulsion. Sonicate water to obtain an aqueous suspension, and finally obtain the...
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