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Method for Synthesizing Chiral Alcohols by Asymmetric Reduction of Prochiral Carbonyl Compounds by Optical Drive Biocatalysis

A technology of carbonyl compounds and biocatalysis, applied in the direction of microorganism-based methods, biochemical equipment and methods, microorganisms, etc., to achieve the effect of simple cultivation conditions and low-cost production processes

Inactive Publication Date: 2011-12-21
WUHAN UNIV OF SCI & TECH
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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a method for synthesizing chiral alcohols through the asymmetric reduction of biocatalyzed prochiral carbonyl compounds, which overcomes the prior art of using microbial cell catalysis and plant tissue catalysis to synthesize chiral alcohols by reducing prochiral carbonyl compounds. Defects

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  • Method for Synthesizing Chiral Alcohols by Asymmetric Reduction of Prochiral Carbonyl Compounds by Optical Drive Biocatalysis
  • Method for Synthesizing Chiral Alcohols by Asymmetric Reduction of Prochiral Carbonyl Compounds by Optical Drive Biocatalysis

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specific Embodiment approach

[0017] This embodiment comprises the following steps:

[0018] 1. Algae cultivation

[0019] Add 1 part of algae seed solution and 49 parts of culture medium into the photosynthetic reactor, and continuously pass CO into the photosynthetic reactor 2 The volume ratio to air is 5%-10%: 95%-90% of the mixed gas, the ventilation rate is 0.1vvm (vvm is the gas flow unit per minute per culture volume), the temperature is 25-30°C, and the light The intensity is 7000-12000lux, and the condition of pH6-8 is cultivated for 2-9 days.

[0020] 2. Chlorella catalyzes the asymmetric reaction process of prochiral ketones

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Abstract

The invention relates to a method for biocatalyzing the reduction of a prochiral carbonyl compound to synthesize a chiral alcohol. It uses green algae as a biocatalyst, and when the OD685nm of the green algae is greater than or equal to 3.0, a prochiral carbonyl compound substrate is added to a photosynthetic bioreactor. Keep the reaction temperature in the photosynthetic reactor at 25-30°C, and the light intensity at 7000-12000lux, so that the green algae cells can fully contact with the prochiral carbonyl compound substrate, and the optical drive biocatalysis reaction occurs; after the reaction is complete, the product is extracted. The invention adopts the novel biocatalyst of green algae, and the cultivation condition of the biocatalyst is simple. In addition, the green algae biocatalyst uses photosynthesis to carry out biological reactions without the assistance of other energy, and can also fix CO2 during the reaction process to achieve carbon emission reduction. It is an efficient, green, safe and low-cost production process.

Description

technical field [0001] The invention relates to a production method of high-value chiral alcohols, in particular to a method for synthesizing chiral alcohols through asymmetric reduction of chiral carbonyl compounds before optical drive biocatalysis. Background technique [0002] Chiral drugs play an important role and status in disease prevention and treatment. According to the research of Frost & Sullivan, a world-renowned consulting company, the global sales of single enantiomer drugs reached more than 170 billion US dollars in 2005, with an annual growth rate of more than 10%. Among the new drugs currently under development, single enantiomer drugs account for 60%. It is estimated that by 2020, this proportion will reach 70%. In addition to its key role in medicine, chiral technology is also increasingly important in agrochemicals, flavors and fragrances, and high-performance functional materials. [0003] Biocatalysis research teams at home and abroad have conducted ...

Claims

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Application Information

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IPC IPC(8): C12P7/02C12R1/89
Inventor 杨忠华罗莉周卫常煦
Owner WUHAN UNIV OF SCI & TECH
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