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Application of rapamycin in the treatment of early brain injury of subarachnoid hemorrhage

A subarachnoid, rapamycin technology, applied in cardiovascular system diseases, nervous system diseases, drug combinations, etc., to achieve the effects of enhancing autophagy, reducing EBI, and reducing cerebral edema

Inactive Publication Date: 2011-12-14
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at this stage, no one has studied the intervention of autophagy to control early brain injury after subarachnoid hemorrhage

Method used

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  • Application of rapamycin in the treatment of early brain injury of subarachnoid hemorrhage
  • Application of rapamycin in the treatment of early brain injury of subarachnoid hemorrhage
  • Application of rapamycin in the treatment of early brain injury of subarachnoid hemorrhage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] 1. Materials:

[0031] 1.1 Reagents and experimental equipment

[0032] 1.1.1 Main Drugs and Reagents

[0033] Rapamycin (RAP) (purchased from Sigma-aldrich, USA), 3-MA (purchased from Sigma-aldrich, USA), Evans blue (purchased from Shanghai Baoman Biotechnology Co., Ltd.), 50% trichloroacetic acid ( TCA), absolute ethanol, etc.

[0034] 1.1.2 Main Instruments

[0035] Electronic scale (FA2004B Shanghai Yueping Technology Instrument Co., Ltd.), oven (DHG9070B Shanghai Langgan Experimental Equipment Co., Ltd.), homogenizer (985-370 BIOSPEC PRODUCTS, INC), centrifuge (GL-16A Shanghai Fischer Analytical Instrument Co., Ltd. company), spectrophotometer (UV-757 Shanghai Mapoda Instrument Co., Ltd.), stereotaxic instrument (ALCB10 Shanghai Alcott Biotechnology Co., Ltd.), 5-μL micro sample injector (Shanghai Gaoge Industry and Trade Co., Ltd. )Wait

[0036] 1.2 Experimental animals

[0037] Adult healthy male Sprague-Dawley (S-D) rats were provided by the Experimental A...

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Abstract

The invention discloses an application of rapamycin of formula (I) in the preparation of a pharmaceutical composition for treating early brain injury after subarachnoid hemorrhage. The present invention proves through experiments that RAP can enhance autophagy, reduce brain edema, reduce the permeability of the blood-brain barrier and alleviate clinical symptoms, thereby alleviating EBI after SAH, and then protecting the brain tissue, providing a basis for the treatment of EBI after SAH A new approach to treatment.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to the application of rapamycin in treating early brain injury of subarachnoid hemorrhage. Background technique [0002] Subarachnoid hemorrhage (SAH) refers to the flow of blood into the subarachnoid space after intracranial blood vessel rupture. Subarachnoid hemorrhage is generally divided into two categories: brain injury and non-injury (spontaneous). Flowing into the subarachnoid space is called primary subarachnoid hemorrhage; 2. Due to intraparenchymal hemorrhage, blood penetrates the brain tissue and enters the subarachnoid space, which is called secondary subarachnoid hemorrhage. Spontaneous SAH is a fatal disease with a mortality rate as high as 32%-67%, of which aneurysmal SAH accounts for more than 85%. Over the past few decades, rerupture hemorrhage and cerebral vasospasm have been considered to affect SAH patients An important prognostic facto...

Claims

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Application Information

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IPC IPC(8): A61K31/436A61P9/00A61P25/00
Inventor 王中陈罡石晓勇
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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