A targeted drug composition for treating liver cancer

A technology for treating liver cancer and a composition, applied in the field of biomedicine, can solve problems such as weakening the anti-angiogenesis effect of bevacizumab, and achieve the effects of inhibiting tumor growth, inhibiting tumor angiogenesis and improving therapeutic effect.

Inactive Publication Date: 2011-11-30
SHANGHAI FIRST PEOPLES HOSPITAL
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AI Technical Summary

Problems solved by technology

Preliminary research on the mechanism of this phenomenon found that low-dose bevacizumab in vivo can induce positive feedback in tumor tissue to enhance the expression of angiogenesis-promoting factors such as VEGF, thereby weakening the anti-angiogenic effect of bevacizumab

Method used

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  • A targeted drug composition for treating liver cancer

Examples

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Effect test

Embodiment 1

[0025] Example 1: MIT+bevacizumab combined inhibition of liver cancer angiogenesis and tumor growth

[0026] 1. Experimental animals: 8-week-old BALB / c nude mice provided by the Experimental Animal Center of Shanghai Branch of the Chinese Academy of Sciences

[0027] 2. Experimental materials: MIT, bevacizumab, low-metastatic human liver cancer cell lines, MHCC97-HG (CGMCC No: 1063) and MHCC97-LG (CGMCC No: 1062).

[0028] 3. Experimental method: using the above-mentioned liver cancer cell line, subcutaneous injection and orthotopic planting to establish animal models, and detecting the effect of different doses of NS / LgG scheme, MIT scheme, bevacizumab scheme and different dosage groups of the pharmaceutical composition of the present invention on inhibiting tumor tissue Angiogenesis and anti-tumor growth effects.

[0029] 4. Experimental results: bevacizumab (25 μg, 50 μg, 100 μg) produced dose-dependent inhibition of angiogenesis and anti-tumor growth, and MIT (0.1 mg / kg) ...

Embodiment 2

[0030] Example 2 Combined therapy of MIT+bevacizumab inhibits angiogenesis and tumor growth of pancreatic cancer

[0031] 1. Experimental animals: 8-week-old BALB / c nude mice provided by the Experimental Animal Center of the Shanghai Branch of the Chinese Academy of Sciences,

[0032] 2. Experimental materials: MIT, bevacizumab, pancreatic cancer cell lines PANC-1 and BxPC3,

[0033] 3. Experimental method: Using the above-mentioned pancreatic cancer cell lines, subcutaneous injection and orthotopic implantation to establish tumor-bearing animal models, testing different doses of NS / LgG regimens, MIT regimens, bevacizumab regimens, and different dose combinations of MIT+bevacizumab combined with new chemotherapy regimens Effects of four chemotherapy regimens on inhibiting tumor angiogenesis and anti-tumor growth.

[0034]4. Experimental results: When chemotherapy was performed when the tumor reached the size required by the experiment, bevacizumab (25 μg, 50 μg, 100 μg) produ...

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Abstract

The invention belongs to the field of biomedicine and relates to a targeted drug for treating tumors in biomedicine, in particular to a targeted drug composition for treating liver cancer. The targeted pharmaceutical composition of the present invention includes a low dose of 0.10 mg / kg / time shimmering mycin MIT and 25 μg / time anti-VEGF antibody drug; the present invention has carried out in vivo liver cancer, gastric cancer, pancreatic cancer tumor-bearing nude mouse model experiments, observed Effects on tumor angiogenesis and the cytokines that regulate its production. The results show that MIT alone in a lower safe dose range can neither affect the normal physiological activities of experimental animals nor inhibit liver tumor angiogenesis and growth or only have a weak effect; but when given the pharmaceutical composition of the present invention, It can inhibit tumor angiogenesis, and then inhibit the growth of liver tumors without increasing drug toxicity.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a targeted drug for treating tumors in biomedicine, in particular to a targeted drug composition for treating liver cancer. Background technique [0002] Clinical research shows that the morbidity and mortality of malignant tumors are increasing year by year, and it has become a major disease that seriously affects people's health. At present, tumor therapy has entered the era of molecular targeting. Theoretically speaking, the anti-angiogenesis treatment strategy that targets and inhibits tumor supply blood vessels has the characteristics of broad anti-tumor spectrum, less resistance to drugs, and easy access of drugs to target sites, which has become a hot research topic in tumor biotherapy. Tumor angiogenesis is a complex process involving multiple cell proliferation, apoptosis, and extracellular matrix degradation and remodeling. Among them, the transcription factor SP1 in tumor cel...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61P35/00A61K31/704
Inventor 王理伟
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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