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The use of coriander root total saponins in the preparation of hypoglycemic drugs

A total saponin and hypoglycemic technology, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., to achieve the effect of simple method, low production cost and high content of total saponin

Active Publication Date: 2011-11-30
西藏自治区高原生物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in the prior art of developing and utilizing fennel root, there is no report on the hypoglycemic effect of total saponins from fennel root

Method used

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  • The use of coriander root total saponins in the preparation of hypoglycemic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Using method A, take the sun-dried coriander root tubers and crush them to 100 mesh, stir with 3 times the volume of 50% ethanol in a water bath at 30°C for 8 hours, filter with suction to obtain a crude extract, repeat the extraction 4 times, and combine the filtrates. Concentrate the filtrate by rotary evaporation under reduced pressure at 30°C, dissolve the obtained extract in hot water at 30°C, the extract volume / water volume is 1:2.5, add petroleum ether at a volume ratio of 1:1 for extraction, and remove fat-soluble impurities. Repeated extraction with n-butanol for 3 times, recovering n-butanol under reduced pressure to obtain crude total saponins. The obtained crude total saponins were dissolved in a small amount of anhydrous methanol, and then ethyl acetate (1:0.5 by volume ratio) was added dropwise, stirred and mixed evenly, and total saponins were precipitated. The treatment was repeated 5 times, and the precipitated total saponins were collected and freeze-d...

Embodiment 2

[0039] Using method A, the sun-dried coriander root tubers were crushed to 40 mesh, stirred with 6 times the volume of 75% ethanol in a water bath at 80°C for 6 hours, suction filtered to obtain a crude extract, repeated extraction twice, and the filtrates were combined. Concentrate the filtrate by rotary evaporation under reduced pressure at 70°C, dissolve the extract in hot water at 70°C, the volume of the extract / water volume is 1:2, add petroleum ether at a volume of 1:2 for extraction, and remove fat-soluble impurities. Repeated extraction with n-butanol for 5 times, and recovering n-butanol under reduced pressure to obtain crude total saponins. The obtained crude total saponins were dissolved in a small amount of anhydrous methanol, and then ethyl acetate (1:0.8 by volume ratio) was added dropwise, stirred and mixed evenly, and total saponins were precipitated. Repeat the treatment 5 times, collect the precipitated total saponins, and dry under reduced pressure and vacuu...

Embodiment 3

[0041] Using method A, take the sun-dried coriander root tubers and crush them to 200 mesh, stir with 10 times the volume of 95% ethanol in a water bath at 65°C for 8 hours, filter with suction to obtain a crude extract, repeat the extraction 4 times, and combine the filtrates. Concentrate the filtrate by rotary evaporation under reduced pressure at 65°C, dissolve the extract in hot water at 55°C, the volume of the extract / water volume is 1:2, add petroleum ether at a volume of 1:1 for extraction, and remove fat-soluble impurities. Repeated extraction with n-butanol for 6 times, and recovering n-butanol under reduced pressure to obtain crude total saponins. The obtained crude total saponins were dissolved in a small amount of anhydrous methanol, and then ethyl acetate (1:0.5 by volume ratio) was added dropwise, stirred and mixed evenly, and total saponins were precipitated. Repeat the treatment 5 times, collect the precipitated total saponins, and dry under reduced pressure an...

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Abstract

The invention relates to application of turnip total saponins extracted from turnip plants to preparing a hypoglycemic medicament. The turnip total saponins can be used for lowering blood sugar of an alloxan-induced diabetic mouse and simultaneously improving pathological changes of visceral organs; meanwhile, related tests of pharmacological effectiveness are performed on animal hyperglycemia caused by adrenalin; and a result shows that the medicament has an obvious effect on lowering blood sugar.

Description

technical field [0001] The invention relates to the use of total saponins extracted from daphne root plants to prepare hypoglycemic drugs, and belongs to the field of medicinal natural products. Background technique [0002] A large number of epidemiological studies have shown that abnormally elevated blood sugar is a risk factor for diabetes. Diabetes is a common endocrine and metabolic disease and the third major disease that endangers human health after cardiovascular disease and cancer. Because diabetes has the characteristics of high prevalence rate, disability rate and high complication rate, it has become one of the diseases that the medical field has paid much attention to and paid more attention to. [0003] Most of the current hypoglycemic drugs are Western medicines or large compound prescriptions of traditional Chinese medicines. Western medicines (including injections and oral hypoglycemic drugs) have strong and rapid effects. Excessive doses cause hypoglycemia ...

Claims

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Application Information

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IPC IPC(8): A61K36/31A61P3/10A61K125/00
Inventor 蒋思萍高平
Owner 西藏自治区高原生物研究所
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