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Probiotic formulations

A probiotic and bacterial strain technology, applied in the directions of antibacterial drugs, suppository delivery, medical raw materials derived from bacteria, etc., can solve the problems of unfavorable effects of lactic acid bacteria and bifidobacteria, and cannot be used to prevent infection, etc.

Inactive Publication Date: 2011-11-23
BRACCO IMAGINIG SPA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0037] However, as the aforementioned prior art documents disclose compositions comprising chelates whose bactericidal or even sterilizing properties are expected to be exploited, said compositions cannot be used to prevent and / or treat infections in human cavities , because its effect on the actual presence of lactic acid bacteria and bifidobacteria in the flora of healthy individuals will also be detrimental

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Beverage preparation

[0107] A powder suitable for the preparation of a drink comprising lactobacilli and at least one small molecular weight non-proteinaceous iron chelate is formulated to have the following composition:

[0108]

[0109] 7g portions of this powder were filled into dispensing bags under low humidity conditions and sealed. A single dose of the drink is the contents of one dispensing bag resuspended in a glass of water.

Embodiment 2

[0111] Beverage preparation

[0112]Similar to Example 1, the powder containing the selected lactobacillus strain and small molecular weight non-proteinaceous iron chelate is prepared, wherein the chelating agent is the same amount of calidol, i.e. [10-(2-hydroxypropyl)- 1,4,7,10-tetraazadodecane-1,4,7-triacetic acid (3-)-N 1 , N 4 , N 7 , N 10 , O 1 , O 4 , O 7 , O 10 ] Calcium (1-), calcium (2:1), abbreviated as Ca 3 (HP-DO3A) 2 .

Embodiment 3

[0114] Beverage preparation

[0115] A powder suitable for the preparation of a drink comprising the selected strain of Lactobacillus and at least one small molecular weight non-proteinaceous iron chelate is formulated to have the following composition:

[0116]

[0117] 7g portions of this powder were filled into dispensing bags under low humidity conditions and sealed. A single dose of the drink is the contents of one dispensing bag resuspended in a glass of water.

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Abstract

The present invention relates to probiotic compositions and kits thereof, comprising live bacteria belonging to the natural flora of the human body cavity such as intestine and vaginal tract, in particular, strains of lactobacillus or bifidobacterium species, and low molecular-weight non-proteinaceous iron chelators capable of lowering the iron concentration over the whole physiological pH-range of relevance to levels that inhibit growth of pathogens, but which allow for the growth of the bacteria of the composition.

Description

[0001] The present invention relates generally to probiotic and therapeutic formulations and in particular to compositions comprising lactic acid bacteria or bifidobacteria and having low molecular weight non-proteinaceous iron chelates for use in the treatment of infections of the human cavity. Background of the invention [0002] Infections of human cavities, such as the female genital tract and bowel, are widespread pathological conditions known to affect (even recurrently affect) a majority of the human population. [0003] Antibiotics are frequently used against these pathological conditions, despite the fact that their chronic use contributes to the emergence of antibiotic-resistant pathogenic bacterial strains. [0004] Since the emergence of such resistant strains poses a serious risk to humans, there is a great need to develop products for the therapy of body cavity infections that are not based on antibiotics and thus do not lead to the development of antibiotic resis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61K35/745A61K35/747
CPCA61K9/02A61K45/06A61K9/0095A61K9/0034A61K35/745A61K9/0036A61K31/00A61K35/747A61P1/00A61P1/12A61P31/00A61P31/04
Inventor C·德汉恩L·戈齐尼
Owner BRACCO IMAGINIG SPA
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