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Medicinal injection for treating delirium

A technology for injections and drugs, applied in the field of medicine, can solve problems such as irritation, difficulty in ensuring drug stability, and swelling and pain at the injection site

Active Publication Date: 2011-11-23
JIANGXI JEMINCARE GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The Xingnaojing injection prepared by the prior art adopts adding polysorbate-80 (being commonly called as Tween-80) as its solubilizing agent in the medicinal liquid, and Tween-80 is as a kind of non-ionic surfactant, and can be taken orally. It is considered to be non-toxic, but when it is used for injection, it often has obvious hemolysis, and it is irritating to a certain extent when it is injected intramuscularly, and there will be obvious swelling and pain at the injection site
And after being sterilized by heat or placed for a period of time, the color of the liquid medicine tends to turn yellow, making it difficult to ensure the stability of the medicine, thereby limiting the production, storage and use of injections and infusions.

Method used

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  • Medicinal injection for treating delirium
  • Medicinal injection for treating delirium
  • Medicinal injection for treating delirium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] 1. Weigh 7.5 parts of musk, 30 parts of turmeric, 1 part of borneol, 30 parts of gardenia, 1 part of poloxamer, and 8 parts of sodium chloride for later use;

[0090] 2. Take gardenia and turmeric respectively, process and process them into Chinese herbal pieces according to the "Chinese Pharmacopoeia".

[0091] 3. Mix gardenia and turmeric according to the ratio, add 25 times the amount of purified water, soak at 80°C for 1 hour, distill and extract for 21 hours, and get 17 times the distillate ①;

[0092] 4. Add musk and 10 times the amount of water for injection to the distillate ① according to the ratio, soak at 80°C for 1 hour, and distill and extract for 21 hours to obtain a 17 times distillate ②;

[0093] 5. Grind 1 part of poloxamer, 1 part of borneol and part of the distillate ② in the above ratio, mix well, then add to the remaining distillate ②, and mix evenly.

[0094] 6. Add 8 parts of sodium chloride and refrigerate for 12 hours

[0095] 7. Take the refr...

Embodiment 2

[0097] 1. Weigh 7.5 parts of musk, 30 parts of turmeric, 1 part of borneol, 30 parts of gardenia, 10 parts of poloxamer, and 8 parts of sodium chloride for later use;

[0098] 2. Take gardenia and turmeric respectively, process and process them into Chinese herbal pieces according to the "Chinese Pharmacopoeia".

[0099] 3. Mix gardenia and turmeric according to the ratio, add 25 times the amount of purified water, soak at 80°C for 1 hour, distill and extract for 20 hours, and obtain a 17 times distillate ①;

[0100] 4. Add musk and 10 times the amount of water for injection to the distillate ① according to the ratio, soak at 80°C for 1 hour, and distill and extract for 20 hours to obtain a 17 times distillate ②;

[0101] 5. Grind and mix 10 parts of poloxamer, 1 part of borneol and part of the distillate ②, then add the remaining distillate ② and mix evenly.

[0102] 6. Add 8 parts of sodium chloride and refrigerate for 12 hours

[0103] 7. Take the refrigerated liquid, fil...

Embodiment 3

[0105] 1. Weigh 7.5 parts of musk, 30 parts of turmeric, 1 part of borneol, 30 parts of gardenia, 100 parts of poloxamer, and 8 parts of sodium chloride for later use;

[0106] 2. Take gardenia and turmeric respectively, process and process them into Chinese herbal pieces according to the "Chinese Pharmacopoeia".

[0107] 3. Mix gardenia and turmeric according to the proportion, add 25 times the amount of purified water, soak at 80°C for 1 hour, distill and extract for 22 hours, and obtain a 17 times distillate ①;

[0108] 4. Add musk and 10 times the amount of water for injection to the distillate ① according to the ratio, soak at 80°C for 1 hour, and distill and extract for 22 hours to obtain a 17 times distillate ②;

[0109] 5. Grind and mix 100 parts of poloxamer, 1 part of borneol and part of the distillate ② in the above proportion, then add to the remaining distillate ② and mix evenly.

[0110] 6. Add 8 parts of sodium chloride and refrigerate for 12 hours

[0111] 7....

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Abstract

The invention relates to a medicinal injection for treating delirium and a preparation method thereof, and relates to application of poloxamer to the preparation of refreshment calming injections. The medicinal injection is processed by using 7.5 parts of musk, 30 parts of turmeric root-tuber, 1 part of borneol, 30 parts of bupleurum, gardenia and 1 to 200 parts of poloxamer serving as a solubilizer.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a drug injection for treating coma and a preparation method thereof. Background technique [0002] Xingnaojing Injection is a drug injection used for the treatment of coma, included in the "National Drug Standards", the standard number is WS 3 -B-3353-98-2003. [0003] [Prescription] Musk 7.5g, Turmeric 30g, Borneol 1g, Gardenia 30g [0004] 【Preparation method】The above four flavors, turmeric and gardenia add about 1500ml of water to distill, collect 1000ml of distillate; add musk to the above distillate, add 250ml of distilled water for distillation, collect 1000ml of distillate, and set aside; take borneol, add 5g of polysorbate 80, grind well, add to the distillate, mix well, add sodium chloride for injection or glucose, stir to dissolve, mix well, place; refrigerate overnight, filter, pot, st...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K47/34A61K9/08A61P25/00A61P7/02A61K31/045A61K35/55
Inventor 刘薇薇
Owner JIANGXI JEMINCARE GRP CO LTD
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