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Sustained release tablet prepared from raw material of safflower yellow and preparation method thereof

A technology of safflower yellow pigment and sustained-release tablet, which is applied in the directions of anti-inflammatory agent, antidote, pill delivery, etc., can solve the problems of inconvenient application of injections, high side effects, etc.

Inactive Publication Date: 2011-11-23
辽宁省中医药研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of injection in the existing safflower yellow preparation is inconvenient, and the higher side effects have caused widespread concern: the reported oral sustained-release matrix tablets and phospholipid complex osmotic pump capsules have avoided the inconvenience and side effects of injection, but Considering the absorption site and mechanism of safflower yellow after oral administration, intragastric sustained-release preparation is the best way of administration, which is more conducive to the absorption and curative effect of safflower yellow

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation prescription composition: drug raw material: auxiliary material=50%: 50%, wherein auxiliary material is made up of hydroxypropyl methylcellulose, sodium carboxymethylcellulose, ethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, and their ratio The relationship is hydroxypropyl methyl cellulose: sodium carboxymethyl cellulose: ethyl cellulose: polyvinyl alcohol: polyvinyl pyrrolidone = 55: 4: 3: 5: 1, and the drug raw material is safflower yellow pigment.

[0019] Preparation method: dissolve the prepared amount of polyvinylpyrrolidone in 95% ethanol, take safflower yellow pigment and 1 / 2 of the prepared amount of hydroxypropyl methylcellulose, ethyl cellulose, and polyvinyl alcohol auxiliary materials to make a soft material , passed through a 60-mesh sieve, dried, and granulated. Get the remaining hydroxypropyl methylcellulose, ethylcellulose, polyvinyl alcohol, 2 / 3 of the prepared amount of sodium carboxymethylcellulose and mix evenly, use 95% ethan...

Embodiment 2

[0021] Preparation prescription composition: drug raw material: auxiliary material=40%: 60%, wherein auxiliary material is made up of hydroxypropyl methylcellulose, sodium carboxymethylcellulose, ethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, and their ratio The relationship is hydroxypropyl methyl cellulose: sodium carboxymethyl cellulose: ethyl cellulose: polyvinyl alcohol: polyvinyl pyrrolidone = 35: 6: 1: 2: 2, and the drug raw material is safflower yellow pigment.

[0022] Preparation method: dissolve the prepared amount of polyvinylpyrrolidone in 95% ethanol, take safflower yellow and 1 / 2 the prepared amount of hydroxypropyl methylcellulose, ethyl cellulose, and polyvinyl alcohol as auxiliary materials to make a soft material , passed through a 60-mesh sieve, dried, and granulated. Get the remaining hydroxypropyl methylcellulose, ethylcellulose, polyvinyl alcohol, 1 / 2 prepared amount of sodium carboxymethylcellulose and mix evenly, make soft material with 95% ...

Embodiment 3

[0024] Preparation prescription composition: drug raw material: auxiliary material=30%: 70%, wherein auxiliary material is made up of hydroxypropyl methylcellulose, sodium carboxymethylcellulose, ethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, and their ratio The relationship is hydroxypropyl methylcellulose: sodium carboxymethylcellulose: ethylcellulose: polyvinyl alcohol: polyvinylpyrrolidone=35:3:1:5:3; the drug raw material is safflower yellow.

[0025] Preparation method: dissolve the prepared amount of polyvinylpyrrolidone in 95% ethanol, take safflower yellow and 1 / 2 the prepared amount of hydroxypropyl methylcellulose, ethyl cellulose, and polyvinyl alcohol as auxiliary materials to make a soft material , passed through a 60-mesh sieve, dried, and granulated. Get the remaining hydroxypropyl methylcellulose, ethylcellulose, polyvinyl alcohol, 1 / 2 prepared amount of sodium carboxymethylcellulose and mix evenly, make soft material with 95% ethanol, pass through ...

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Abstract

The invention aims to provide a sustained release tablet prepared from raw material of safflower yellow and a preparation method thereof. The sustained release tablet is characterized by being a gastric floating sustained release tablet and comprising components in a weight ratio of a medicament raw material to accessories equal to 30-50%:50-70%. The medicament raw material is safflower yellow, and the accessories comprise components in a weight ratio of hydroxypropyl methyl cellulose to carboxymethylcellulose sodium to ethyl cellulose to polyvinyl alcohol to vinylpyrrolidone equal to 35-55:4-8:1-3:3-5:1-3. According to the preparation technology, a secondary granulation and an internal and external accessory adding method are employed to mix the medicament raw material and the accessories; and 95% ethanol liquid of polyvinylpyrrolidone and 95% ethanol are used as adhesives respectively.

Description

technical field [0001] The invention relates to the field of preparation of a modern drug delivery system of traditional Chinese medicine, in particular to a prescription composition and a preparation method of a traditional Chinese medicine which uses safflower yellow pigment, which is an extract of safflower, as a raw material to prepare a floating slow-release tablet in the stomach. Background technique [0002] With the improvement of people's living standards, people's requirements for drugs are also increasing. They require drugs with good curative effect, small side effects, convenient administration, good compliance, and affordable prices. They require the market to produce new dosage forms of more humanized drug delivery systems. For this reason, the dosage form research of the modern drug delivery system has been developed rapidly, from the first generation of conventional dosage forms such as ordinary tablets, pills, granules, injections, etc. to the second generat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/351A61K47/38A61P9/10A61P7/02A61P9/12A61P39/06A61P29/00A61P37/06A61P25/00
Inventor 于绍军赵金明张宏刘晶陈贺孟莉杨月妍靖博宇
Owner 辽宁省中医药研究院
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