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Schistosomiasis protective agent used for cattle, namely niclosamide spraying agent and preparation method thereof

A technology for niclosamide and schistosomiasis, applied in the direction of aerosol delivery, anti-infective drugs, drug combinations, etc., can solve the problems of lack of methods for preventing and controlling schistosomiasis infection in cattle, and achieve the control of schistosomiasis prevalence, easy operation, The effect of controlling the spread of schistosomiasis

Inactive Publication Date: 2011-11-23
JIANGSU INST OF PARASITIC DISEASES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cattle are the most important source of infection for schistosomiasis. At present, there is still a lack of effective prevention and treatment methods to control cattle infection with schistosomiasis. It is difficult to implement measures such as replacing cattle with machines and prohibiting grazing.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1: the preparation of niclosamide spray

[0010] In terms of mass, 5 parts of niclosamide are dissolved in 10 parts of ethyl acetate, 2 parts of azone and 1 part of Span 60 are added, stirred and added to 82 parts of absolute ethanol to obtain niclosamide spray agent.

Embodiment 2

[0011] Embodiment 2: the preparation of niclosamide spray

[0012] On a mass basis, 5 parts of niclosamide are dissolved in 5 parts of ethyl acetate, 2 parts of azone and 5 parts of Span 60 are added, stirred and added to 83 parts of absolute ethanol to obtain niclosamide spray agent.

Embodiment 3

[0013] Embodiment 3: the preparation of niclosamide spray

[0014] On a mass basis, 1 part of niclosamide is dissolved in 15 parts of dimethyl sulfoxide, 1 part of azone and 1 part of Span 60 are added, stirred and added to 82 parts of absolute ethanol to obtain niclosamide Amine spray.

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PUM

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Abstract

The invention relates to a schistosomiasis protective agent used for cattle, namely niclosamide spraying agent and a preparation method thereof, belonging to the technical field of protective agent medicines used for preventing cattle from being infected by schistosomiasis. In parts by mass, 0.5-5 parts of niclosamide is dissolved into 5-20 parts of cosolvent, 0.5-2 parts of penetrant and 1-5 parts of emulsifier are added, then absolute ethyl alcohol is added under the stirring condition to prepare solution, and the total mass of the solution is 100 part, thus the niclosamide spraying agent is obtained. The spraying agent is sprayed onto the skin of cattle to form a medicine protective layer, the cattle can be effectively prevented from being infected by schistosome in 15-30 days, spread of schistosomiasis is controlled, and human health is protected while sustainable development of animal husbandry is promoted. The niclosamide spraying agent provided by the invention is simple in preparation method, is convenient to use and can prevent and control prevalence of schistosomiasis among people while the cattle is protected from being infected by schistosome.

Description

technical field [0001] The invention discloses a schistosomiasis protective agent for cattle-niclosamide spray and a preparation method thereof, belonging to the technical field of drug protective agents for preventing schistosomiasis infection of cattle. Background technique [0002] Schistosomiasis japonicum is a major infectious disease that seriously endangers the health of our people, and it is a zoonotic disease. Cattle are the most important source of infection of schistosomiasis. At present, there is still no effective control method to control the infection of schistosomiasis in cattle. It is difficult to implement measures such as replacing cattle with machines and prohibiting grazing. The technology of bovine schistosomiasis protective agent is to use niclosamide, which has high efficiency, low toxicity and low price, which has a good effect of killing schistosomiasis cercariae. Under the action of penetrant, etc., a layer of drug protection layer is formed on th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/167A61P33/12
Inventor 戴建荣梁幼生邢云天李洪军
Owner JIANGSU INST OF PARASITIC DISEASES
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