Microelectrode array-based multichannel neural information detection system

Abstract

The invention discloses a microelectrode array-based multichannel neural information detection system and relates to neurobiological detection technology. The microelectrode array-based multichannel neural information detection system comprises an analogue switch array, an electrophysiological signal detection circuit, an electrochemical signal detection circuit, an electrical stimulation signal generation circuit, multiple analogue to digital (A-to-D) converter circuits, a temperature detection circuit, a high-speed universal serial bus (USB) transmission circuit, a wireless Bluetooth communication module, data processing software to be run on a computer and the like. The multichannel neural information detection system disclosed by the invention can be used for acquiring electrophysiological and electrochemical neural information of in vivo animals or in vitro tissue; and by combining with different kinds of microelectrode arrays, the multichannel neural information detection systemcan detect the electrophysiological and electrochemical signals of a plurality of neurons in a two-dimensional or three-dimensional scale, acquire more complete and accurate experimental data, and realize bidirectional and double-mode application and implementation of neurons.

Description

technical field [0001] The invention relates to the technical field of neurobiological detection, and is a detection system for simultaneously detecting the electrophysiological activities of multiple neurons and the changes of neurotransmitters. Background technique [0002] The information transmission of nerve cells is completed by pulse discharge and neurotransmitters (chemical substances). Simultaneously detecting changes in electrophysiological signals and neurotransmitter content is of great importance for studying the pathogenesis of certain diseases, nerve signal transmission, and drug responses. Scientific significance and clinical value. At the same time, the response of organisms to external events and every process of information processing requires the joint action of many nerve cells. To reveal the complex mechanism, the electrical activity information of a sufficient number of nerve cells must be obtained. Traditional electrode or single microelectrode techn...

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Problems solved by technology

[0003] The purpose of the present invention is to disclose a multi-channel neural information detection system based on a microelectrode array, which controls the functional arrangement of the microelectrode array through computer software to meet the requirements of different experiments, and simultaneously detects neurophysiological and electrochemical signals , to solve the problem of continuous, multi-channel detection of nerve cells and detection of weak electrophysiological and electrochemical signals

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