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Application of pharmaceutical composition in preparing medicament for treating type 2 diabetes mellitus due to lipotoxicity by reducing SREBP1-C

A composition and drug technology, applied in the field of pharmacy, can solve the problems of insulin deficiency, insulin loss, synthesis limitation, etc.

Active Publication Date: 2011-11-09
北京中一堂科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ability to produce insulin in patients with type 2 diabetes is not completely lost, and some patients even produce too much insulin, but the effect of insulin is greatly reduced, so the insulin in the patient's body may be in a state of relative deficiency
Patients with type 2 diabetes sometimes need to use insulin therapy, but most of them are because of poor blood sugar control, or because of acute complications or severe chronic complications of diabetes, not for life support like type 1 diabetes patients
Studies have shown that the increase of SREBP-1c will limit the synthesis of proteins that act on insulin in the liver, thereby reducing the action of insulin, which is closely related to insulin resistance

Method used

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  • Application of pharmaceutical composition in preparing medicament for treating type 2 diabetes mellitus due to lipotoxicity by reducing SREBP1-C
  • Application of pharmaceutical composition in preparing medicament for treating type 2 diabetes mellitus due to lipotoxicity by reducing SREBP1-C
  • Application of pharmaceutical composition in preparing medicament for treating type 2 diabetes mellitus due to lipotoxicity by reducing SREBP1-C

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0325] Embodiment 1, the preparation of Tangminling Capsules of the present invention

[0326] Take 30g of Tianhuafen, 12g of Bupleurum, 9g of Citrus aurantium, 3g of raw rhubarb, 6g of pinellia, 9g of baicalin, 6g of coptis, 9g of white peony, 15g of black plum, 9g of hawthorn, 9g of sealwort, 9g of ginseng, and 9g of bitter gourd;

[0327] Add 4 times the amount of 80% ethanol, reflux and extract at 60°C for 3 times, each time for 1.5 hours, combine the extracts, recover the ethanol under pressure at 70°C, dry in vacuum at 80°C, crush and pass through an 80-mesh sieve to obtain the drug extract;

[0328] Lactose is added to make capsules.

Embodiment 2

[0329] Embodiment 2, the preparation of Tangminling tablet of the present invention

[0330] Take 30g of Tianhuafen, 12g of Bupleurum, 9g of Citrus aurantium, 3g of raw rhubarb, 6g of pinellia, 9g of baicalin, 6g of coptis, 9g of white peony, 15g of black plum, 9g of hawthorn, 9g of sealwort, 9g of ginseng, and 9g of bitter gourd;

[0331] Add 4 times the amount of 80% ethanol, reflux and extract at 60°C for 3 times, each time for 1.5 hours, combine the extracts, recover the ethanol under pressure at 70°C, dry in vacuum at 80°C, crush and pass through an 80-mesh sieve to obtain the drug extract;

[0332] Add dextrin to make tablets.

Embodiment 3

[0333] Embodiment 3, the preparation of Tangminling Granules of the present invention

[0334] Take 30g of Tianhuafen, 12g of Bupleurum, 9g of Citrus aurantium, 3g of raw rhubarb, 6g of pinellia, 9g of baicalin, 6g of coptis, 9g of white peony, 15g of black plum, 9g of hawthorn, 9g of sealwort, 9g of ginseng, and 9g of bitter gourd;

[0335] Add 4 times the amount of 80% ethanol, reflux and extract at 60°C for 3 times, each time for 1.5 hours, combine the extracts, recover the ethanol under pressure at 70°C, dry in vacuum at 80°C, crush and pass through an 80-mesh sieve to obtain the drug extract;

[0336] Blast drying at 60°C, granulation, and sizing to obtain granules.

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Abstract

The invention belongs to the medical field, and relates to an application of a pharmaceutical composition in preparing a medicament for reducing SREBP1-c, wherein the pharmaceutical composition is prepared by the following traditional Chinese medicine raw materials by weight: 540 parts of trichosanthin, 10-30 parts of radix bupleuri, 3-15 parts of citrus aurantium, 1-6 parts of raw rhubarb, 1-12 parts of pinellia tuberifera, 3-15 parts of radix scutellariae, 1-12 parts of coptis, 3-15 parts of white peony roots, and 5-20 parts of dark plums.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to the application of a pharmaceutical composition in treating type 2 diabetes. Background technique [0002] Type 2 diabetes mellitus (T2DM) is a worldwide public health problem that seriously threatens human health. Statistics published by the International Diabetes Federation (IDF) in 2006 show that in the past 20 years, the number of diabetic patients in the world has increased from 30 million to 230 million. Experts from the World Health Organization predict that by 2025, there will be 350 million people with diabetes worldwide. India, China, and the United States are the three countries with the largest number of diabetic patients in the world. It is estimated that the total number of diabetic patients in China is nearly 40 million, second only to India, ranking second in the world, accounting for 29.63% of the world. The prevention and treatment of T2DM will be a serious challenge for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8888A61K36/8969A61P3/06A61P3/10
Inventor 仝小林甄重常柏周水平
Owner 北京中一堂科技有限公司
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