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Method for establishing water molecule diffusion model in human brain

A technology of model building and method building, applied in medical science, special data processing applications, instruments, etc., can solve the problem of not being able to objectively, quickly and accurately display the diffusion mode of extracellular water molecules, high sensitivity, time-consuming and labor-intensive, and operable issues such as reliability, to increase repeatability, reduce subjective errors, and improve efficiency

Inactive Publication Date: 2011-10-19
THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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Problems solved by technology

Manual drawing of ROI has the disadvantages of strong subjectivity, time-consuming and laborious, and poor operability, and cannot objectively, quickly and accurately display the diffusion mode of extracellular water molecules
[0005] Before the present invention, a small number of international research institutions used voxel-based (VBM) Statistical Parameter Mapping (SPM) to analyze magnetic resonance images. voxel variation, resulting in hypersensitivity

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  • Method for establishing water molecule diffusion model in human brain
  • Method for establishing water molecule diffusion model in human brain
  • Method for establishing water molecule diffusion model in human brain

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Embodiment Construction

[0027] The technical idea of ​​the present invention is to use the existing knowledge of the brain region delineation in the brain atlas to automatically segment the images mapped to the brain atlas, thereby realizing brain function analysis at the level of brain regions, and applying it to cognitive dysfunction diseases.

[0028] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only for illustrating the invention and are not intended to limit the scope of the invention.

[0029] 1. Technical scheme of the present invention

[0030] Such as figure 1 Shown:

[0031] Concrete implementation steps of the present invention are:

[0032] (1) Collect the brain apparent diffusion coefficient image of the subject;

[0033] (2) The researchers evaluate the image quality according to the image definition and other indicators, if the quality does not meet the requirements, return to step (1);

[...

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Abstract

The invention relates to a method for establishing a water molecule diffusion model in human brain. The method comprises the following steps of: acquiring a cerebral apparent diffusion coefficient image; converting the diffusion coefficient image acquired from nuclear magnetic resonance equipment from a format of DICOM to a format of ANALYZE 7.5; mapping the diffusion coefficient image to a cerebral image template through non-linear registration; segmenting the cerebral apparent diffusion coefficient image into a plurality of anatomical brain regions; calculating a grey-scale average value and a variance of voxels forming each anatomical brain region; and establishing the water molecule diffusion model in the human brain by using a variance analysis and agglomerate T detection method. By the method, defects of overhigh sensitivity and strong objectivity of a method for analyzing a magnetic resonance image based on a statistical parameter mapping of the voxels are overcome. In the invention, a method for researching an extracellular water molecule diffusion pattern in cognitive disorders based on levels of the anatomical brain regions is established, the method is implemented by compiling image processing software. The change of a single voxel caused by accidental factors is avoided, and the subjectivity of determining a cluster threshold is avoided.

Description

technical field [0001] The invention relates to the establishment of a model, in particular to a method for establishing a water molecule diffusion model in the human brain. Background technique [0002] Amnestic mild cognitive impairment (aMCI) is a transitional period between normal aging and Alzheimer's disease (AD), and about 12-15% of patients progress to Alzheimer's disease every year. The use of magnetic resonance imaging can provide objective evidence for predicting the progression of amnestic mild cognitive impairment to Alzheimer's disease. [0003] Functional magnetic resonance diffusion-weighted imaging (DWI) and its apparent diffusion coefficient (ADC value) can be used to detect the diffusion movement of extracellular water molecules in living cells. When the extracellular space increases due to various reasons such as cell atrophy, the ADC value increases. In Alzheimer's disease patients, the ADC values ​​in hippocampus, temporal lobe trunk, posterior cingula...

Claims

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Application Information

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IPC IPC(8): G06F19/00A61B5/055
Inventor 张剑戈张冰郭万华李茗张鑫朱斌徐运
Owner THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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