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Cream medicine composition and preparation method thereof

A technology of composition and medicine, applied in the field of cream for treating foot fungal infection and its preparation, can solve the problems of pathogenic fungus residue, easy recurrence, poor permeability, etc.

Active Publication Date: 2011-10-12
福州中科伟创生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although there are many drugs for treating tinea pedis, most of them have poor permeability in the skin of the foot, and the drugs only contact with the surface of the skin of the foot, resulting in residual pathogenic fungi of tinea pedis under the cortex, which is easy to relapse

Method used

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  • Cream medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Take every 100 kg of cream as an example:

[0107] Preparation of water phase components: pump 49.35Kg of deionized water into the water phase tank and heat to 80°C. When the temperature reaches 80°C, turn on the stirring paddle, the stirring speed is 30r / min, then add 2Kg of sodium lauryl sulfate and 2Kg of fatty alcohol polyoxyethylene ether, and stir slowly to dissolve. Keep the temperature of the aqueous phase at 80°C.

[0108] Preparation of oil phase components: Add 9.0Kg of melted vaseline, 3.5Kg of stearyl alcohol, 9.0Kg of liquid paraffin, 2Kg of sorbitan monostearate, and 3.0Kg of glyceryl monostearate into the oil phase tank in sequence And laurocapram 1.0Kg. Heat to 80°C, turn on the stirring paddle, and the stirring speed is 30r / min. Maintain the substrate temperature at 80°C.

[0109] Preparation of functional components: Weigh 3.0Kg of Melaleuca alternifolia essential oil, stir and dissolve with 4.0Kg of propylene glycol, heat to 60°C and keep warm to...

Embodiment 2

[0113] Take every 100 kg of cream as an example:

[0114] Preparation of water phase components: pump 73.85Kg of deionized water into the water phase tank and heat to 80°C. When the temperature reaches 80°C, turn on the stirring paddle, the stirring speed is 30r / min, then add 1Kg of sodium lauryl sulfate and 0.5Kg of fatty alcohol polyoxyethylene ether, and stir slowly to dissolve. Keep the temperature of the aqueous phase at 80°C.

[0115] Preparation of oil phase components: Add 5.0Kg of melted vaseline, 2.0Kg of stearyl alcohol, 5.0Kg of liquid paraffin, 0.5Kg of sorbitan monostearate, and 2.0 kg of glyceryl monostearate into the oil phase tank in sequence Kg and laurocapram 0.5Kg. Heat to 80°C, turn on the stirring paddle, and the stirring speed is 30r / min. Maintain the substrate temperature at 80°C.

[0116] Preparation of functional components: Weigh 0.5Kg of Melaleuca alternifolia essential oil, stir and dissolve with 2.0Kg of propylene glycol, heat to 60°C and keep...

Embodiment 3

[0120] Take every 100 kg of cream as an example:

[0121]Preparation of water phase components: pump 28.85Kg of deionized water into the water phase tank and heat to 80°C. When the temperature reaches 80°C, turn on the stirring paddle, the stirring speed is 30r / min, then add 5Kg of sodium lauryl sulfate and 2Kg of fatty alcohol polyoxyethylene ether, and stir slowly to dissolve. Keep the temperature of the aqueous phase at 80°C.

[0122] Preparation of oil phase components: Add 12.0Kg of melted vaseline, 8Kg of stearyl alcohol, 10Kg of liquid paraffin, 2Kg of sorbitan monostearate, 6.0Kg of glyceryl monostearate and laurel into the oil phase tank in sequence Azone 2.0Kg. Heat to 80°C, turn on the stirring paddle, and the stirring speed is 30r / min. Maintain the substrate temperature at 80°C.

[0123] Preparation of functional components: Weigh 5.0Kg of Melaleuca alternifolia essential oil, stir and dissolve with 5.0Kg of propylene glycol, heat to 60°C and keep warm to prepa...

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Abstract

The invention relates to a cream medicine composition for treating and preventing foot superficial fungal infection and a preparation method thereof. The cream is prepared from the following components: melaleucaleucadendron essential oil, L-menthyl lactate, camphor, menthol, laurocapram and cream substrates, wherein the cream substrates comprise vaseline, octadecanol, atoleine, dehydrated sorbitan monostearate, GMS (Glycerin Monostrearate), dimethyl silicone oil, fatty alcohol polyoxyethylene ether, sodium lauryl sulfate, propylene glycol, emulsified silicone oil and the like. The cream has a scientific formula and has the effects of preventing the foot superficial fungal infection and relieving foot skin itch. Proved by experiments, the melaleucaleucadendron essential oil in the cream can highly penetrate into the skin surface, has a remarkable effect of preventing the pathogenic foot superficial fungal infection and is an effective preparation for preventing the foot superficial fungal infection. Proved by a mouse infection experiment, the effective ratio of the cream disclosed by the invention to prevent the foot superficial fungal infection of a mouse is up to 90.5%. The preparation process flow of the preparation is reasonable, chemical structures of various raw materials and a penetration auxiliary agent are not broken, and the operation is easy to carry out.

Description

technical field [0001] The invention relates to a medicinal composition of cream and a preparation method thereof, in particular to a cream for treating foot fungal infection and a preparation method thereof. Background technique [0002] There are many types of foot fungal infections, but the main disease is tinea pedis. Tinea pedis refers to the fungal infection dermatosis that occurs in the toes, soles, and soles of the feet, and is a chronic infectious dermatosis. The cause of the disease is mainly due to the infection of the skin of the feet by fungi such as Epidermophyton, Trichophyton or Trichophyton toe. Tinea pedis can cause symptoms such as thickening of the cuticle of the foot skin, dryness, severe itching, and easy sweating. At present, although there are many drugs for treating tinea pedis, most of them have poor permeability in the skin of the foot, and the drugs only contact with the surface of the skin of the foot, resulting in residual pathogenic fungi of ...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61K9/06A61K47/44A61P17/00
Inventor 吴燕斌肖永堂符友伟
Owner 福州中科伟创生物科技有限公司
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