Nitrofurazone washing fluid, preparation method and application thereof

Abstract

The invention discloses a novel nitrofurazone washing fluid, which mainly comprises an active component nitrofurazone, a solubilizing agent polyethyleneglycol 15-hydroxyl stearate and a solvent injection water. Furthermore, one or more of cosolvent, pH regulator, osmotic pressure regulator and stabilizing agent can be added into the washing fluid. In the washing fluid, a novel solubilizer Solutol HS 15 has low haemolysis, extremely low histamine liberation and higher physiological tolerance, so that safety of clinical administration and compliance of patients are remarkably improved; the washing fluid has excellent stability and longer validity, and higher administration convenience is given to clinical doctors; and the washing fluid has better storage and transportation stability, higher clinical administration safety and patient compliance. The washing fluid has a simple preparation process, convenience in quality control, lower production cost and industrial production.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to a medical product for wound disinfection, more specifically to a wound antibacterial rinse solution for reducing the microbial content of the wound and its preparation method and application, and more specifically The invention relates to a nitrofurazone flushing solution and a preparation method and application thereof. Background technique [0002] (1) Basic situation of nitrofurazone research [0003] 1 Overview [0004] Furacilin Irrigation Solution (Furacilin Irrigation Solution) is generally divided into Furacilin Irrigation Solution and Sterilized Furacilin Irrigation Solution. It is a commonly used clinical preparation in medical institutions and is recorded in "Chinese Hospital Preparation Standards" (Second Edition of Western Medicine Preparations). [0005] As a local antibacterial drug commonly used in clinical practice in hospitals, nitrofurazone solution ...

AI Technical Summary

Problems solved by technology

[0020] 1. Those who are allergic to furan drugs should not use it

[0021] 2. Allergic reactions after oral administration, such as shock, asthma, shortness of breath, rash, etc.; gastrointestinal reactions, drug fever, eosinophilia and neurological symptoms such as auditory hallucinations, visual hallucinations, hallucinations, dizziness, insomnia and multiple seizures Peripheral neuritis, etc.

[0113] Its disadvantage is that the fibers washed with it feel bad

Disadvantages of lead salt stabilizers: poor dispersibility, high toxicity, initial coloring, difficult to obtain transparent products, and difficult to obtain brightly colored products, lack of lubricity, easy to produce sulfur pollution

[0390] ② Calcium stearate (CaSt), good processing performance, high thermal stability, no vulcanization pollution, non-toxic, but poor transparency

[0438] Through literature search, etc., so far, no new nitrofurazone flushing solution product report has been found, which not only ensures stable quality, can be used in large-scale industrial production, but also can significantly reduce the toxic and side effects of the product.

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