Hydrogel forming covalent cross-linking rapidly under mild conditions and preparation method thereof

Abstract

The invention discloses a hydrogel forming covalent cross-linking rapidly under mild conditions and a preparation method thereof. The hydrogel contains two components, i.e. NHS (N-Hydroxy Succinimide) ester of PEG (Polyethylene Glycol) and PEG containing N-terminal group cysteine. The two components are dissolved and mixed to obtain the hydrogel. The hydrogel disclosed by the invention can form covalent cross-linking rapidly under mild conditions, and is particularly suitable for being manufactured into surgical sealants.

Description

technical field [0001] The invention relates to a hydrogel and a preparation method thereof, in particular to a hydrogel capable of rapidly forming covalent crosslinks under mild conditions and a preparation method thereof. Background technique [0002] Hydrogel (Hydrogel) is a hydrophilic polymer network structure, insoluble in water, but can absorb and retain a large amount of water, highly swellable in aqueous solution, and has good biocompatibility and similarity. They can be used in surgical sealants and adhesives, drug release, tissue repair and tissue engineering in the field of medicine and biology. [0003] Existing hydrogel systems are usually formed through chemical or physical actions. Chemical crosslinking to form aqueous gels often involves the use of toxic crosslinking agents and free radicals, and the resulting hydrogels are usually not biodegradable. On the other hand, physical hydrogels are formed through non-covalent interactions, such as hydrogen bonds,...

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Problems solved by technology

This FocalSeal as a surgical sealant ? The disadvantage of the hydrogel system is that it is somewhat difficult to control in practice

However, since the two solutions disclosed in WO2008 / 131325 are mixed to form a hydrogel slowly (about 3 minutes), it is not suitable as a surgical sealant

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