Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of compounds, solvates, in the field of compounds useful as protein kinase inhibitors
Inactive Publication Date: 2011-08-31
ABBOTT LAB INC
View PDF18 Cites 3 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, their affinity and selectivity or their pharmacological profiles are not yet satisfactory
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
[0338] (S)-2-amino-2-phenylethanol (1.04g, 7.61mmol), tert-butylchlorodimethylsilane (1.15g, 7.62mmol), triethylamine (2.15ml, 15.4mmol), N , N-dimethylpyridin-4-amine (23mg, 0.19mmol) / dichloromethane solution was stirred overnight at room temperature, quenched with saturated aqueous NaHCO3, extracted with dichloromethane, dried (Na 2 SO 4 ), filtered, and concentrated to give 1.85 g of a clear oil, which was used without purification.
[0341] A solution of the product of Example 1A (127mg, 0.505mmol), triphosgene (52.1mg, 0.176mmol), and triethylamine (0.25ml, 1.8mmol) / dichloromethane (2ml) was stirred at room temperature for 2 hours. 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine (0.10 g, 0.50 mmol) was added and stirred at room temperature for 2 hours. N,N-Dimethylformamide (1 ml) was added to dissolve, and the mixture was stirred overnight, diluted with ethyl acetate, washed with water and brine, dried (Na 2 SO 4 ), filtered, concentrated and chromatographed (3% methanol / dichloromethane) to give the product as a clear gum (0.186 g, 0.391 mmol).
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
Disclosed herein are compounds of formula (I) or pharmaceutical acceptable salts thereof, wherein A, X<1>, X<2>, R<1>, R<2>, R<3>, m, n, and p are defined in the specification. Compositions including the compounds which can be useful for inhibiting Rho kinase (ROCK) and methods for using the compositions are also described.
Description
technical field [0001] Bicyclic compounds that are inhibitors of Rho kinase (ROCK), compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions are provided. Background technique [0002] An important large family of enzymes is the protein kinase enzyme family. Currently, there are approximately 500 different known protein kinases. ATP-Mg 2+ The transfer of the y-phosphate of the complex to the amino acid side chain catalyzes the phosphorylation of the amino acid side chain in various proteins. [0003] These enzymes control much of the intracellular signal processing whereby cellular function, growth, differentiation and destruction (apoptosis) are governed by reversible phosphorylation of the hydroxyl groups of serine, threonine and tyrosine residues in proteins. Research has shown that protein kinases are key regulators of many cellular functions, including signal transduction, regulation of transcripti...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more