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Plant extract composition for preventing and treating arteriosclerosis and preparation method thereof

A technology of plant extracts and arteriosclerosis, which is applied in the direction of drug combinations, plant raw materials, medical preparations containing active ingredients, etc., can solve the problem that the active ingredients cannot be properly purified, affect the stability of the clinical efficacy of the product, and cause problems for patients. Taking compliance is not ideal and other problems, to achieve the effect of lowering serum total cholesterol, lowering serum triglyceride level, and controllable product quality

Active Publication Date: 2011-08-24
青岛百里才鑫医药科技有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0008] Although there are many traditional Chinese medicine compounds that have good blood lipid regulation and anti-arteriosclerosis functions and clinical curative effects, but because they are traditional Chinese medicine compound preparations, there are still many shortcomings: (1) Its ingredients are relatively complicated, and its active ingredients are not clear, It is not easy to quantify, and will eventually affect the stability of the clinical efficacy of the product. (2) Relatively simple preparation process, the active ingredients in the prescription cannot be purified as they should, there are many impurities, the dosage is large, and the compliance of patients is not ideal. (3) Due to the large amount of prescription extracts, the scope of application is subject to various restrictions

Method used

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  • Plant extract composition for preventing and treating arteriosclerosis and preparation method thereof
  • Plant extract composition for preventing and treating arteriosclerosis and preparation method thereof
  • Plant extract composition for preventing and treating arteriosclerosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of the plant extract composition of embodiment 1 preventing and treating arteriosclerosis

[0035] One, the preparation of Panax notoginseng total saponins extract

[0036] (1) Panax notoginseng saponins extract

[0037] Weigh 10 kg of Panax notoginseng medicinal material, pulverize it, and reflux extraction with 75% ethanol of 8 times, 8 times and 6 times the amount of the medicinal material, respectively, for 3 times, 2 hours each time, and filter the combined extracts with a 200-mesh filter cloth, and combine the filtrates. Recover the ethanol and make the concentration of the ethanol extraction part 1ml equivalent to 1g crude drug concentrate (1.9 L); absorb on a macroporous resin column, the macroporous resin is HPD-100 of the polystyrene weakly basic anion exchange resin series, press 1 Add 1.5L of concentrated solution to kg resin and adsorb on a macroporous resin column, wash with water until the eluate is nearly colorless, then elute with 4.5 L...

Embodiment 2

[0082] Example 2 Effect of Plant Extract Composition for Preventing and Treating Arteriosclerosis on Experimental Rat Arteriosclerosis

[0083] Experimental animals: SD rats, SPF grade, male, weighing 200 g±20 kg.

[0084] Method: After the rats were adaptively fed for one week, they were randomly divided into normal group, model group, and low, medium, and high-dose groups of plant extract compositions for preventing and treating arteriosclerosis (hereinafter referred to as low-dose group, middle-dose group, and high-dose group) ), Panax notoginseng total saponins extract (referred to as PSE) group, Coptis chinensis total alkaloid extract (referred to as HAE) group and FTZ (Compound Zhenzhu Tiaozhi Fang) group. Among them, 10 rats in the normal control group were fed with basic feed, 80 rats in the model group, and the model group and each administration group received a one-time intraperitoneal injection of vitamin D3 600,000 units / kg, and fed high-fat feed and 10 mL / kg per ...

Embodiment 3

[0102] Example 3 The effect of the plant extract composition for preventing and treating arteriosclerosis on the proliferation of vascular smooth muscle cells induced by oxidized low-density lipoprotein

[0103] Methods: Referring to Wang Daosheng's patch method (Wang Daosheng, Arterial smooth muscle cell culture method, see Pharmacological Experiment Methodology edited by Xu Shuyun, Beijing: People's Health Publishing House, 2001:573), 6-week-old male SD rats were decapitated and sacrificed , the media of the thoracic aorta was taken, and cultured in DMEM medium containing 10% fetal bovine serum by patch method, placed at 37°C, 5% CO 2 Cultured in an incubator for primary culture of rat vascular smooth muscle cells. Using the 3rd to 5th generation vascular smooth muscle cells, the oxidized low-density lipoprotein (Ox-LDL) induced vascular smooth muscle cell proliferation experiment was carried out, and the effect of different concentrations of traditional Chinese medicine com...

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Abstract

The invention discloses a plant extract composition for preventing and treating arteriosclerosis, which comprises a panax notoginseng saponin extract and a total coptis alkaloid extract. The invention also discloses a preparation method for the composition, which comprises the following steps of: performing C1-3 alcohol extraction on pseudo-ginseng, mixing to obtain a total extract, concentrating, and removing nonsaponin components from the total extract to obtain the panax notoginseng saponin extract; and adding C1-3 alcohol into golden thread for reflux extraction, recovering the C1-3 alcohol, concentrating, dissolving alkaloid precipitate with acid for recrystallization, separating out the total coptis alkaloid extract, and mixing the panax notoginseng saponin extract and the total coptis alkaloid extract to obtain the plant extract composition for preventing and treating arteriosclerosis. A large number of ineffective chemical components in the conventional compound Chinese traditional medicine are removed, the active ingredient content is greatly improved, and the influence of the ineffective components on product processing and preparation quality and safety is reduced, so that the active ingredients are definite, the preparation process is stable, the product quality is controllable, the industrial production is facilitated, the medicinal effect of resisting arteriosclerosis is obviously improved, and the effect of preventing and treating the arteriosclerosis is more stable and better.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract composition, in particular to a plant extract composition for preventing and treating arteriosclerosis and a preparation method thereof. Background technique [0002] Arteriosclerosis is a common and frequently-occurring disease in middle-aged and elderly people. Atherosclerosis (Atherosclerosis, AS) is the most common and important type of arteriosclerosis, which is characterized by the deposition of lipids and the accumulation of complex carbohydrates in the intima of the affected arteries, followed by fibrous tissue hyperplasia and calcium deposition, and There is a lesion in the arterial media. The disease mainly involves large and medium-sized muscular elastic arteries, especially the aorta, coronary arteries, and cerebral arteries. It often leads to serious consequences such as occlusion of the lumen or rupture and bleeding of the vessel wall, and is the main cause of myocardial inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61P9/10
CPCA61K36/718A61K36/258A61P9/10A61K2300/00
Inventor 郭姣
Owner 青岛百里才鑫医药科技有限公司
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