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Ointment for treating burns and scalds

A technology for burns and ointments, which is applied in the direction of ointment delivery, medical preparations containing active ingredients, organic active ingredients, etc. It can solve the problems of affecting epithelialization, plaster coating, poor air permeability, and inability to solve pain, etc.

Inactive Publication Date: 2011-06-08
邓守恒
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Silver sulfadiazine and silver nitrate cream belong to silver ion drugs. The disadvantage is that silver ions can combine with the DNA of epithelial cells, affect epithelialization, and even deepen the wound surface, which has a negative impact on wound healing
Moist burn ointment, compound Xueyu charcoal ointment, and Mihong ointment cannot solve pain and other problems in clinical practice, and they are all oily ointments, which are not conducive to the application of plasters on burns and have poor air permeability

Method used

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  • Ointment for treating burns and scalds
  • Ointment for treating burns and scalds
  • Ointment for treating burns and scalds

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Selenized chitosan solid dispersion 20g, cetyl alcohol 150g, borneol 10g, sodium lauryl sulfate 10g, vaseline 400g, glycerin 55g, 5~10% paraben absolute ethanol solution 15ml, add distilled water to the total preparation The amount is 1000g.

[0019] Preparation method: ①Preparation of solid dispersion: Using solvent melting method, accurately weigh the carrier (poloxamer 188) and raw material (selenized chitosan) according to (1:9, W / W), and place the carrier in the In an evaporating dish, heat it in a water bath at 70°C until it melts, then add chitosan selenide dissolved in acetone, and stir continuously until a uniform transparent liquid is formed. Dry in a vacuum drying oven at 50°C for 24 hours, take it out and pulverize it, pass through an 800 mesh sieve, and store it in a desiccator for later use; ②Preparation of drug solution: take the formula amount of selenized chitosan solid dispersion, add 3 times the amount of water to dissolve, Stir well. Take the formu...

Embodiment 2

[0021] Selenized chitosan solid dispersant 35g, cetyl alcohol 160g, borneol 15g, sodium lauryl sulfate 15g, vaseline 390g, glycerin 55g, 5~10% paraben absolute ethanol solution 25ml, add distilled water to the preparation total The amount is 1000g.

[0022] Preparation method: ①Preparation of solid dispersion: Using solvent melting method, accurately weigh the carrier (poloxamer 188) and raw material (selenized chitosan) according to (1:9, W / W), and place the carrier in the In an evaporating dish, heat it in a water bath at 70°C until it melts, then add chitosan selenide dissolved in acetone, and stir continuously until a uniform transparent liquid is formed. Dry in a vacuum oven at 50°C for 24 hours, take out and pulverize, pass through a 800-mesh sieve, and store in a desiccator for future use. ②Preparation of drug solution: take the formula amount of chitosan selenide solid dispersion, add 2 times the amount of water to dissolve, and stir evenly. Get formula quantity born...

Embodiment 3

[0024] Selenized chitosan solid dispersant 50g, cetyl alcohol 150g, borneol 20g, sodium lauryl sulfate 20g, vaseline 410g, glycerin 60g, 5~10% paraben absolute ethanol solution 30ml, add distilled water to the preparation total The amount is 1000g.

[0025] Preparation method: ①Preparation of solid dispersion: Using solvent melting method, accurately weigh the carrier (poloxamer 188) and raw material (selenized chitosan) according to (1:9, W / W), and place the carrier in the In an evaporating dish, heat it in a water bath at 70°C until it melts, then add chitosan selenide dissolved in acetone, and stir continuously until a uniform transparent liquid is formed. Dry in a vacuum oven at 50°C for 24 hours, take out and pulverize, pass through a 800-mesh sieve, and store in a desiccator for future use. ②Preparation of drug solution: take the formula amount of chitosan selenide solid dispersion, add 2 times the amount of water to dissolve, and stir evenly. Get formula quantity born...

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Abstract

The invention provides an ointment for treating burns and scalds, which comprises the following components in parts by weight: 20-50 parts of chitosan selenide solid dispersing agent, 150-160 parts of hexadecanol, 10-20 parts of borneol, 10-20 parts of lauryl sodium sulfate, 390-410 parts of Vaseline, 50-60 parts of glycol, 15-30ml of 5-10% nipagin absolute ethyl alcohol solution and the balance of distilled water for supplementing the total weight of the preparation to 1000g. Compared with the traditional burn cream in the market, the ointment does not belong to an oily medicinal cream, can be used for not only favorably promoting the healing of a wound surface, but also alleviating pains brought by the scalded wound surface, has good air permeability, and is easy to apply and accept by patients.

Description

technical field [0001] The invention relates to a medicine for external use, in particular to an ointment for treating burns and scalds. Background technique [0002] At present, exposure therapy is used clinically for the treatment of large-area Ⅰ-Ⅲ degree burns, that is, treatment with lamp roasting or infrared radiation to reduce exudation and anti-infection. For small-area burns, drug coating exposure or semi-exposure treatment is often used. Drugs mainly include silver sulfadiazine, silver nitrate cream, MEBO, compound Xueyu charcoal ointment, Mihong ointment, etc. Silver sulfadiazine and silver nitrate cream belong to silver ion drugs. The disadvantage is that silver ions can combine with the DNA of epithelial cells, affect epithelialization, and even deepen the wound surface, which has a negative impact on wound healing. Moist burn ointment, compound Xueyu charcoal ointment, and Mihong ointment cannot solve pain and other problems clinically, and they are all oily oi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61K9/06A61P17/02A61K31/045
Inventor 邓守恒陈萍喻雄杰杨敬宁曹凤军李芳吴方毅任妮丽瞿萍魏娟吴亚玲
Owner 邓守恒
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