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Antimicrobial agent, method of preparing an antimicrobial agent and articles comprising the same

An anti-microbial agent and anti-microbial technology are applied in the fields of inhibiting the growth of microbial substances, producing anti-microbial articles, and anti-microbial compositions, and can solve the problems of insufficient research on the anti-microbial performance of dialdehyde polysaccharides.

Inactive Publication Date: 2011-06-01
UNIV OF FLORIDA RES FOUNDATION INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the use of dialdehyde polysaccharides as antimicrobial agents has been studied to some extent, the antimicrobial performance of dialdehyde polysaccharides has not been fully studied

Method used

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  • Antimicrobial agent, method of preparing an antimicrobial agent and articles comprising the same
  • Antimicrobial agent, method of preparing an antimicrobial agent and articles comprising the same
  • Antimicrobial agent, method of preparing an antimicrobial agent and articles comprising the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Example 1: Evaluation of the effect of DAS on bacteria

[0113] This example serves to demonstrate the antibacterial activity of heated DAS against three different strains of Gram-negative bacteria and three different strains of Gram-positive bacteria. The minimum lethal concentration (MLC) of DAS against Gram-negative and Gram-positive bacteria is shown in Table 3.

[0114] Table 3: MLC (weight percent) of DAS showing 7 log reduction in bacteria after 1 hour exposure test.

[0115]

EC

ST

PA

SA

EF

BC

DAS(%)

0.8

2.1

1

0.8

1

0.2

pH

3.2

2.9

3.1

3.2

3.1

3.5

[0116] After the heating or "boiling" step, the DAS suspension in water is acidic. To understand the antimicrobial effect of DAS on bacteria (ie, whether acid or aldehyde functional groups contribute to the antimicrobial effect), additional experiments were performed. Use PBS and DAS to study the effect ...

Embodiment 2

[0119] Example 2: Effect of DAS Ultrasonic Treatment on Bacterial Inactivation

[0120]This example serves to demonstrate the antibacterial activity of sonicated DAS against Gram-negative and Gram-positive bacterial strains. DAS samples (2.7 wt%) were sonicated for different times and the effect of sonication on the antibacterial activity of DAS was evaluated. The pH values ​​of 2.7% DAS sonicated for different times were almost the same, ie about pH 3. Figure 7 The results in show the effect of DAS sonication time on bacterial log reduction. Such as Figure 7 As shown, sonication of DAS for at least 15 minutes resulted in a significant increase in the antimicrobial activity of DAS against EC (Gram-negative) and SA (Gram-positive). These results also confirmed that the antimicrobial activity of DAS was attributed to the activity of aldehyde groups. The particle size of DAS in the sonicated suspension is micron. Once the DAS gel was broken by sonication, more aldehyde gro...

Embodiment 3

[0121] Embodiment 3, assess the effect of DAS on bacterial virus

[0122] This example is used to demonstrate the antiviral activity of DAS against bacterial viruses. For phage experiments, heated DAS samples were used. The antiviral activity of DAS against two bacterial viruses (PRD1 and MS2) is shown in Figure 7 and 8 middle. Unlike the effect of pH on the antibacterial activity of PBS, no effect of pH on the antiviral activity of PBS against these two bacterial viruses was observed. In both low pH (pH=3) and high pH (pH=8.7) samples, DAS was able to completely kill PRD1 and MS2 phage during the 4 hour incubation. However, if Figure 8 As shown, at pH=8.7, DAS can completely kill MS2 phage in only 1 hour. Such as Figure 7 As shown, a lower level of activity against PRD1 was observed. At pH = 3, the level of activity of DAS against PRD1 was higher than that against MS2 in the 1 hour test. Compared to the antibacterial results, the activity of DAS against bacterial ...

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Abstract

The present disclosure is directed to method of preparing an antimicrobial agent comprising heating a dialdehyde polysaccharide. The method comprises subjecting a dialdehyde polysaccharide, such as a dialdehyde starch or a dialdehyde cellulose, to heating and / or sonication for a period of time. Also provided herein is an antimicrobial composition comprising the prepared dialdehyde polysaccharide. The antimicrobial composition is effective at killing microbial agents such as viruses and bacteria within a short period of time.

Description

Background technique [0001] Currently, there are several major, potentially catastrophic challenges plaguing health officials around the world. One of these potential challenges is avian influenza, also known as "bird flu". Although avian influenza has been reported in human individuals, cases in humans to date have been sporadic and limited. Currently, the spread of avian influenza from one individual to another is limited to bird species. However, experts predict that if bird flu spreads to humans and spreads from person to person, it may lead to a large-scale epidemic. Current strategies for controlling potential infection require immunization of a limited number of first responders and isolation and separation from the community population for up to two weeks. Surgical face masks are also considered a backup strategy for controlling transmission rates, as they are able to partially remove airborne particles produced by coughing or sneezing. However, these masks themsel...

Claims

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Application Information

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IPC IPC(8): A01N43/04A01P1/00
CPCA01N43/16A01N35/02A01N25/04A01N25/34
Inventor 罗纳德·H·巴内塞缪尔·M·法拉宋礼
Owner UNIV OF FLORIDA RES FOUNDATION INC
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