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Method for separating glucosamine hydrochloride from Lentinus edodes leftovers

A technology for glucosamine hydrochloride and shiitake mushroom leftovers, which is applied in the field of separation of glucosamine hydrochloride, can solve the problems of difficult process implementation and industrialization, and achieve simple and feasible technical route, high yield and short hydrolysis time Effect

Inactive Publication Date: 2011-06-01
LANGFANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The production process stated in the above-mentioned patent application "A Production Process for Hydrolyzing and Separating Glucosamine Hydrochloride from Mushrooms" uses dried mushrooms as raw materials to prepare glucosamine directly by acidolysis, which is very difficult in terms of technology. Implementation, in terms of production cost, it is almost difficult to industrialize

Method used

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  • Method for separating glucosamine hydrochloride from Lentinus edodes leftovers
  • Method for separating glucosamine hydrochloride from Lentinus edodes leftovers
  • Method for separating glucosamine hydrochloride from Lentinus edodes leftovers

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Embodiment 1

[0031] Dry 500g of lentinus stalks, alkali hydrolyze in 5000ml of 40% sodium hydroxide solution, temperature 120℃, time 3h. Cool to 25°C, filter, wash the filter residue with 1000ml of pure water, add 5000ml of acetic acid with the raw material weight to the filter residue, the concentration of acetic acid is 10%, and heat and reflux at 95°C for 2.5h. After the solution is cooled, centrifuge at 5000r / min for 5min, and take the supernatant. Titrate the supernatant with 30% sodium hydroxide solution to make the pH of the supernatant ≥10, and white flocculent precipitates continuously precipitate during the titration process. Centrifuge at 5000r / min for 5min, and take the precipitate, and place it at 60℃. drying. Add the above precipitate to an enamel reactor, and then add 5 times the weight of the precipitate with hydrochloric acid, with a hydrochloric acid concentration of 25%; gradually increase the temperature and stir. After the temperature is raised to 95°C, heat and hydrol...

Embodiment 2

[0033] Dry 500g of lentinus stalks, alkali hydrolyze with 5000ml of 35% sodium hydroxide solution, temperature 115℃, time 3.5h. Cool to 25°C, filter, wash the filter residue with 1000ml of pure water, add 5000ml of acetic acid with the raw material weight to the filter residue, the acetic acid concentration is 12%, and heat to reflux at 100°C for 3h. After the solution is cooled, centrifuge at 5000r / min for 5min, and take the supernatant. Titrate the supernatant with 30% sodium hydroxide solution to make the pH of the supernatant ≥10. During the titration, white flocculent precipitates are continuously precipitated. Centrifuge at 5000r / min for 5min, take the precipitate, and place it at 65℃. drying. Add the above precipitate to an enamel reactor, and then add 5 times the weight of the precipitate with hydrochloric acid with a hydrochloric acid concentration of 30%; gradually increase the temperature and stir. After the temperature is raised to 100°C, heat and hydrolyze for 4 h...

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Abstract

The invention relates to a method for separating glucosamine hydrochloride from Lentinus edodes leftovers, which comprises the following steps: sequentially hydrolyzing dried Lentinus edodes stipes with sodium hydroxide, and filtering; heating the precipitate under reflux with acetic acid, and centrifugating; and precipitating the supernatant with sodium hydroxide, hydrolyzing with hydrochloric acid, filtering, carrying out vacuum concentration, crystallizing, centrifugating, and carrying out freeze-drying to obtain the glucosamine hydrochloride. The invention has the following advantages: (1) plant-derived mushrooms are used as the raw material, thereby avoiding the defects of the product anaphylaxis, seasonal restrictions to the raw material, incapability of eating for the vegetarianisms and the like in the glucosamine hydrochloride which is made from shrimp and crab shell chitin by the traditional method; (2) the method does not need the pretreatment with acid or alkali, and the raw material dried citric acid slag is directly hydrolyzed, thereby avoiding the problem of sewage caused by pretreatment with acid and alkali; and (3) the hydrolysis time is short, and is only 2.5-3 hours.

Description

Technical field [0001] The invention relates to the extraction of health products and natural products, in particular to a method for separating glucosamine hydrochloride from shiitake mushroom scraps. Background technique [0002] D-Glucosamine Hydrochloride, the molecular formula is: C 6 H 13 NO 5 ·HCl, molecular weight 215.63, white crystal, is a natural amino polysaccharide, the structural formula is: [0003] [0004] D-glucosamine hydrochloride is the basic unit of many important polysaccharides in biological cells, and has important physiological functions to the human body. It participates in detoxification of the liver and kidneys, plays the role of anti-inflammatory and liver protection; stimulates the growth of bifidobacteria in the intestines of infants; it can specifically act on articular cartilage and restore the normal metabolic function of cartilage cells; it can stimulate cartilage cells to produce normal poly The proteoglycan of the body structure inhibits enzym...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H5/06C07H1/08
Inventor 吴智艳闫训友秘树青史振霞
Owner LANGFANG NORMAL UNIV
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