Therapy device for inactivating pathogenic microorganisms in in-vivo blood by photodynamic therapy

Abstract

The invention discloses a therapy device for inactivating pathogenic microorganisms in in-vivo blood by photodynamic therapy. The device comprises a laser light source, a driving power source, an irradiation cabin and a photosensitizer pump, wherein the driving power source is arranged in a shell for providing electric energy for the therapy device; the irradiation cabin is connected with an extracorporeal circulation channel; the photosensitizer pump is connected with the irradiation cabin; a control panel for controlling the photosensitizer pump and the power density of the laser light source is also arranged in the shell; a fluorescent detector is connected between the control panel and the irradiation cabin; a light source control circuit is connected between the control panel and the laser light source; and the front side face of the shell is provided with an operating panel which is connected with the control panel and the driving power source. Through the therapy device for inactivating the pathogenic microorganisms in the in-vivo blood by the photodynamic therapy, the photodynamic therapy is performed on the blood to inactivate the pathogenic microorganisms in the blood. Since the control panel for controlling the photosensitizer pump and the power density of the laser light source is arranged in the therapy device, the using amount of a photosensitizer and the power density of the laser light source can be adjusted and controlled in real time according to a feedback signal of the fluorescent detector; and the therapy device has stable therapy effect and is convenient to operate.

Description

technical field [0001] The invention belongs to the field of laser medical equipment, in particular to a laser treatment device for inactivating pathogenic microorganisms in blood. Background technique [0002] The photodynamic method of inactivating pathogenic microorganisms is mainly based on the principle that the photosensitizer undergoes a photochemical reaction under laser excitation, and the singlet oxygen or free radicals generated oxidize and damage the molecular structure of the target tissue, thereby inactivating the pathogen. At present, the technology of photodynamic inactivation of pathogenic microorganisms in blood is mainly aimed at in vitro blood tissues, such as plasma products, red blood cell concentrates and white blood cell concentrates. [0003] Chinese patent CN101468206A discloses a "viral inactivation method in extracorporeal circulation blood and its application", which includes the following steps: first, adding an anticoagulant to the whole blood ...

AI Technical Summary

Problems solved by technology

[0008] The present invention aims to solve the technical problem that the curative effect of the device for inactivating pathogenic microorganisms in the body blood by photodynamic therapy is unstable and cannot be regulated in real time in the prior art, and provides a photodynamic therapy inactivation device capable of real-time regulation Device for treating pathogenic microorganisms in blood

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