Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Use of dexamethasone as tool medicament for constructing animal model with kidney-deficiency infertility

A technology of dexamethasone and animal model, which can be applied to medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., and can solve problems such as inhibiting female reproductive function.

Inactive Publication Date: 2012-02-29
吴效科
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are clinical reports that dexamethasone combined with ovulation-inducing drugs promotes ovulation in women, but there is no report that it inhibits female reproductive function

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of dexamethasone as tool medicament for constructing animal model with kidney-deficiency infertility
  • Use of dexamethasone as tool medicament for constructing animal model with kidney-deficiency infertility
  • Use of dexamethasone as tool medicament for constructing animal model with kidney-deficiency infertility

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0011] 1. Experimental method

[0012] The estrous cycle was observed with vaginal smears of 10-week-old sexually mature Kunming white mice (purchased from the Experimental Animal Center of Heilongjiang University of Traditional Chinese Medicine), and mice with normal cycles (n=13) were included in the experiment. Divided into control group (n=6) and experimental group (n=7). The experimental group was given intramuscular injection of dexamethasone 4mg / kg, and the control group was given the same volume of normal saline. Dose once daily.

[0013] 2. Experimental results

[0014] 1. Changes in the estrous cycle.

[0015] After 50 days of continuous administration, vaginal smears were carried out on the mice. It was found that the estrous cycle of the mice in the dexamethasone group was significantly prolonged, which was statistically significant compared with the control group. The experimental results are shown in Table 1.

[0016] Table 1 Changes in the estrous cycle

...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a use of dexamethasone as a tool medicament for constructing an animal model with kidney-deficiency infertility. 4mg / kg of dexamethasone is given to female mice with sexual maturity by intramuscular injection once per day, and the injection is continuously performed by 50 days. The results find that the female mice show withered hair, no gloss, shedding and other kidney-deficiency representations, and the representations that the estrous cycle is prolonged, the number of small follicles and atretic follicles is increased, the number of corpus luteums is reduced, the progesterone is reduced and others showing low fertility simultaneously occur. The experimental results show that the dexamethasone can sustainedly and stably reduce the reproductive function, be used as the tool medicament for constructing the animal model with the kidney-deficiency infertility and provide a foundation for verifying the efficacy of medicaments for improving the fertility.

Description

technical field [0001] The invention relates to a new application of dexamethasone, in particular to the application of dexamethasone as a tool drug for constructing an animal model of kidney deficiency type infertility, and belongs to the field of medical application of dexamethasone. Background technique [0002] Traditional Chinese medicine believes that the kidney governs reproduction, and the kidney governs the storage of the heavenly gui and the sperm cell, which is the foundation of Chong Ren and dominates the production of menstruation. Insufficient kidney essence, deficiency of Chong and Ren, and lack of nourishment of blood vessels will cause the sea of ​​blood not to overflow on time, manifested as oligomenorrhea or amenorrhea, which is one of the main causes of female infertility. In order to verify the clinical efficacy of various drugs in treating kidney deficiency infertility, it is necessary to construct an animal model of kidney deficiency infertility. At p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/573
Inventor 吴效科张跃辉马红丽
Owner 吴效科
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com