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Polyethylene terephthalate and polyurethane composite artificial blood vessel and preparation thereof

A polyethylene terephthalate and artificial blood vessel technology, which is applied in the field of biomedical engineering, can solve the problems of limited improvement of blood vessel elasticity and inability to meet the requirements for the use of small-diameter artificial blood vessels, and the long-term patency rate of large-diameter artificial blood vessels. , to achieve the effect of good elasticity and mechanical properties

Active Publication Date: 2013-07-03
宁波贝昂生物材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degree of improvement in the elasticity of the blood vessels obtained by the weaving method is limited, and it still cannot meet the requirements for the use of small-caliber artificial blood vessels and the goal of further improving the long-term patency of large-caliber artificial blood vessels.

Method used

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  • Polyethylene terephthalate and polyurethane composite artificial blood vessel and preparation thereof

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preparation example Construction

[0033] a solution preparation:

[0034] Dissolve 60-95 parts of polyethylene terephthalate and 5-40 parts of polyurethane in hexafluoroisopropanol solvent, stir until completely dissolved, and make a spinning stock solution with a mass fraction of 5-12% 4;

[0035] b Preparation of artificial blood vessels:

[0036]Put the spinning stock solution 4 prepared by a into the solution cylinder 2 of the electrospinning device with the agitator 3, place the agitator 3 in the solution cylinder 2, and the agitator 3 at a speed of 10 to 50 rpm Stir the spinning stock solution 4 so that the polyethylene terephthalate and polyurethane in the spinning stock solution 4 are evenly mixed, and the artificial blood vessel structure is formed using the drum mold 7 as a receiving device, and the drum mold 7 is located at the nozzle 5 of the electrospinning device Below, its axis is perpendicular to the nozzle 5 of the electrospinning device, the rotation speed of the drum mold 7 is 10 to 100 rp...

Embodiment 1

[0040] a Weigh 4.75g of polyethylene terephthalate and 0.25g of polyurethane (CorethaneTM) on a precision electronic balance, and fully dissolve them in 95g of hexafluoroisopropanol to obtain a spinning stock solution with a concentration of 5%. Wherein the mass ratio between polyethylene terephthalate and polyurethane is 95 / 5.

[0041] The spinning stock solution prepared by b is added to the solution tank for electrospinning, and the agitator stirs the spinning stock solution at a speed of 10 rpm. The drum mold with a diameter of 1 mm is selected as the collecting device, and the rotation speed of the drum mold is set to be 10 revolutions / min, the speed of linear reciprocating motion is 100mm / min. The micro-injection pump pushes the evenly stirred spinning stock solution through the nozzle into the high-voltage electric field with a voltage of 15KV and an electric field distance of 50mm at a propulsion speed of 0.1ml / h. Fiber 6h, forming an artificial blood vessel structure...

Embodiment 2

[0044] a Weigh 8g polyethylene terephthalate and 2g polyurethane ( 80A), fully dissolved in 90g hexafluoroisopropanol to obtain a spinning dope with a concentration of 10%. Wherein the mass ratio between polyethylene terephthalate and polyurethane is 80 / 20.

[0045] The spinning stock solution prepared by b is added to the solution cylinder for electrospinning, and the agitator stirs the spinning stock solution at a speed of 50 rpm. The drum mold with a diameter of 30 mm is selected as the collection device, and the rotation speed of the drum mold is set to be 100 revolutions / min, the speed of linear reciprocating motion is 500mm / min. The micro-injection pump pushes the evenly stirred spinning stock solution through the nozzle into the high-voltage electric field with a voltage of 25KV and an electric field distance of 300mm at a propulsion speed of 0.1ml / h. Fiber 6h, forming an artificial blood vessel structure with an inner diameter of 30 mm and a wall thickness of 100 μm...

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Abstract

The invention discloses a polyethylene terephthalate and polyurethane composite artificial blood vessel and a preparation method thereof, belonging to the field of biomedical engineering. The artificial blood vessel is prepared from polyethylene terephthalate and polyurethane by means of an electrostatic spinning device with a stirrer. The prepared artificial blood vessel is a tubular object witha microporous structure. The polyurethane added in the artificial blood vessel can improve the elasticity of the blood vessel under the condition of not damaging the strength of the polyethylene terephthalate material, increase the compliance of the artificial blood vessel and achieve the requirements of clinical use. The polyethylene terephthalate and polyurethane composite artificial blood vessel has the advantages of high strength, large elasticity and compliance, good biocompatibility, strong anticoagulant property and large cell adhesion, and can meet the requirements of the clinical useof the artificial blood vessels with large diameter and small diameter. The preparation process is simple and practical, and applicable to preparing the artificial blood vessels with various different requirements on mechanical properties.

Description

technical field [0001] The invention relates to a composite artificial blood vessel of polyethylene terephthalate and polyurethane and a preparation method thereof, belonging to the field of biomedical engineering. Background technique [0002] The blood circulation in the human body delivers nutrients and oxygen to various organs, collects waste products in the human body and removes them from the body. Blood vessels are responsible for connecting the heart with other tissues, providing channels for the flow of blood, and adjusting the local balance of the circulatory system. When human blood vessels are damaged or blocked, the blood cannot continue to provide nutrients and oxygen to local tissues, resulting in tissue necrosis, which ultimately threatens the life of the human body. Therefore, when blood vessels cannot work normally due to arteriosclerosis, aging or damage, surgical operations such as artificial blood vessel replacement, bypass or intervention are required ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/26A61L27/18D01D5/00D01D1/02D01D7/00
Inventor 徐卫林杨红军叶青王珍珍崔卫钢李文斌
Owner 宁波贝昂生物材料有限公司
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