Composition used for preventing or treating bone and joint diseases and preparation method thereof

A joint disease and composition technology, applied in the field of composition and its preparation for the prevention or treatment of bone and joint diseases, can solve the problems of safety differences, no differences in curative effects, etc., and achieve the goal of increasing bone density and enhancing repair Effect

Inactive Publication Date: 2011-04-06
北京赛而生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The glucosamine that has been on the market includes glucosamine sulfate and glucosamine hydrochloride. From the perspective of molecular structure, one is hydrochloride and the other is sulfate. Clinically, there is no obvious difference in curative effect between the two, but only from the safety of long-term use. there will be a difference

Method used

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  • Composition used for preventing or treating bone and joint diseases and preparation method thereof
  • Composition used for preventing or treating bone and joint diseases and preparation method thereof
  • Composition used for preventing or treating bone and joint diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Weigh 1750g of raw materials D-glucosamine hydrochloride, 1950g of calcium carbonate, 300g of soybean isoflavones, 120g of microcrystalline cellulose, 80g of magnesium stearate, and 160g of PVP. Mixing, testing, filling capsules with 0.436g per capsule (0.4g in total of D-glucosamine hydrochloride, calcium carbonate and soybean isoflavones), polishing, packaging and testing.

Embodiment 2

[0047] Weigh raw materials D-glucosamine sulfate 1750g, calcium carbonate 1950g, soybean isoflavone 300g, microcrystalline cellulose 140g, magnesium stearate 60g, PVP 200g. Mixing, testing, filling capsules with 0.436g per capsule (0.4g in total of D-glucosamine sulfate, calcium carbonate and soybean isoflavones), polishing, packing and testing.

Embodiment 3

[0049] Weigh 3500g of D-glucosamine hydrochloride, 3900g of calcium carbonate, 600g of soybean isoflavones, 120g of microcrystalline cellulose, 40g of magnesium stearate, and 240g of PVP. Mixing, testing, filling capsules with 0.840 g per capsule (0.8 g in total of D-glucosamine hydrochloride, calcium carbonate and soybean isoflavones), polishing, packing and testing.

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Abstract

The invention provides a composition used for preventing or treating bone and joint diseases. The composition contains D-glucosamine, a calcium compound and soy isoflavone, wherein the weight ratio of the D-glucosamine to the calcium compound to the soy isoflavone is (1.0-5.0): (1.5-5.5): (0.2-1.5). The invention provides a preparation method of the composition. The pharmacological research result shows that the composition has remarkable efficacy of calcium supplement and estrogen-like effect, can effectively inhibit osteoclast functions and prevent and treat osteoporosis, has the function of producing proteoglycan through stimulating chondrocytes, improves the repairing capability of the chondrocytes, and effectively prevents and treats the bone and joint diseases.

Description

technical field [0001] The invention relates to a composition for preventing or treating bone and joint diseases and a preparation method thereof, in particular to a health care composition for preventing osteoporosis and osteoarthropathy, a preparation method thereof and a preparation method for A pharmaceutical composition for treating osteoporosis and osteoarthropathy and a preparation method thereof. Background technique [0002] Bone and joint diseases include osteoporosis and osteoarthropathy. [0003] Osteoporosis is a systemic skeletal disease characterized by decreased bone mass and degeneration of bone microstructure, resulting in increased bone fragility and susceptibility to fractures. [0004] The factors causing bone loss are very complicated. In recent years, studies have suggested that endocrine factors such as decreased secretion of sex hormones (estrogen and testosterone) lead to increased bone resorption; calcium-regulating hormone secretion disorders lea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61P19/02A61P19/10A61K31/352A61K31/7048A61K31/7008
Inventor 马骉孙爽孔双泉
Owner 北京赛而生物药业有限公司
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