Compound medicine containing antihypertensive peptide and aldosterone receptor antagonist for curing hypertension
A receptor antagonist, aldosterone technology, applied in the field of compound pharmaceutical composition, can solve the problem of limited effect
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Embodiment 1-1
[0038] active ingredient
[0039] Spironolactone (particle size 5-20μm) 5.0g
[0040] IPP 100.0g
[0041] Accessories:
[0042] 100g pregelatinized starch
[0043] Microcrystalline Cellulose 100g
[0044] Lactose 180g
[0045] Carboxymethyl Starch Sodium 4g
[0046] Micronized silica gel 5g
[0047] Magnesium Stearate 3g
[0048] Proper amount of povidone aqueous solution
[0049] A total of 1000 pieces were made
[0050] Weigh the active ingredient, pregelatinized starch, microcrystalline cellulose, and lactose according to the prescription amount, pass through a 60-100 mesh sieve respectively, after mixing evenly, add an appropriate amount of povidone aqueous solution to make a soft material, 20 mesh sieve to make granules, and dry. Whole granules, add magnesium stearate, sodium starch glycolate, micropowder silica gel, mix well and press into tablets with a suitable die.
Embodiment 1-2
[0052] active ingredient
[0053] Spironolactone (particle size 5-20μm) 50.0g
[0054] IPP 200.0g
[0055] Accessories:
[0056] 100g pregelatinized starch
[0057] Microcrystalline Cellulose 120g
[0058] Lactose 230g
[0059] Carboxymethyl Starch Sodium 4g
[0060] Micronized silica gel 5g
[0061] Magnesium Stearate 3g
[0062] Proper amount of povidone aqueous solution
[0063] A total of 1000 pieces were made
[0064] Weigh the active ingredient, pregelatinized starch, microcrystalline cellulose, and lactose according to the prescription amount, pass through a 60-100 mesh sieve respectively, after mixing evenly, add an appropriate amount of povidone aqueous solution to make a soft material, 20 mesh sieve to make granules, and dry. Whole granules, add magnesium stearate, sodium starch glycolate, micropowder silica gel, mix well and press into tablets with a suitable die.
Embodiment 1-3
[0066] active ingredient
[0067] Spironolactone (particle size 5-20μm) 100.0g
[0068] IPP 100.0g
[0069] Accessories:
[0070] 120g pregelatinized starch
[0071] Microcrystalline Cellulose 160g
[0072] Lactose 200g
[0073] Carboxymethyl Starch Sodium 4g
[0074] Micronized silica gel 5g
[0075] Magnesium Stearate 3g
[0076] Proper amount of povidone aqueous solution
[0077] A total of 1000 pieces were made
[0078] Weigh the active ingredient, pregelatinized starch, microcrystalline cellulose, and lactose according to the prescription amount, pass through a 60-100 mesh sieve respectively, after mixing evenly, add an appropriate amount of povidone aqueous solution to make a soft material, 20 mesh sieve to make granules, and dry. Whole granules, add magnesium stearate, sodium starch glycolate, micropowder silica gel, mix well and press into tablets with a suitable die.
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