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Method for preparing ginger phenol

A technology of gingerol and ginger, which is applied in the field of preparation of gingerol extracted from plants, can solve the problem of low purity of gingerol monomer, and achieve the effects of large-scale production operations, less pollution, and less energy consumption

Inactive Publication Date: 2011-01-26
SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In the prior art, the industrial production process for extracting gingerol is rarely disclosed. Chinese patent document CN101530607A discloses a method for extracting gingerols, but its products are mainly mixtures, and the purity of gingerol monomers is not high.

Method used

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  • Method for preparing ginger phenol

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Experimental program
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Effect test

Embodiment 1

[0017] Get ginger rhizome 10Kg, add to CO 2 In the supercritical extractor, ethyl acetate is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 50MPa, the temperature is 80°C, and the CO 2 The flow rate is 10L / min, the extraction time is 60min, and the extract is injected into a molecular still for 3-stage molecular distillation. The evaporation surface temperature of the first stage distillation is 50°C, the pressure is 10000Pa, the distillation time is 60min, and the distillate is collected. Carry out the second-stage distillation, the temperature of the evaporation surface is 100°C, the pressure is 160Pa, distill for 40min, collect the distillate, carry out the third-stage distillation, the temperature of the evaporation surface is 60°C, the pressure is 160Pa, collect the distillate to obtain ginger 5.4g of phenol, detected by HPLC, has a purity of 96.3%.

Embodiment 2

[0019] Get ginger rhizome 10Kg, add to CO 2 In the supercritical extractor, ethyl acetate is used as an entrainer, and the entrainer accounts for 10% by volume of the total extraction solvent, the extraction pressure is 80MPa, the temperature is 100°C, the CO2 flow rate is 30L / min, and the extraction time is 120min to obtain the extract, inject Carry out three-stage molecular distillation in a molecular still, wherein the evaporation surface temperature of the first stage distillation is 60°C, the pressure is 15000Pa, and the distillation time is 80min, and the distillate is collected for the second stage distillation. 180Pa, distilled for 80min, collected the distillate, and carried out the third stage distillation. The evaporation surface temperature was 60°C, and the pressure was 180Pa. Collected the distillate to obtain 6.5g of gingerol, which was detected by HPLC with a purity of 95.4%.

Embodiment 3

[0021] Get ginger rhizome 10Kg, add to CO 2 In the supercritical extractor, ethyl acetate is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 8%, the extraction pressure is 60MPa, the temperature is 90°C, and the CO 2 The flow rate is 20L / min, and the extraction time is 100min. , to obtain the extract, which is injected into a molecular still for 3-stage molecular distillation, wherein the evaporation surface temperature of the 1st-stage distillation is 55°C, the pressure is 12000Pa, and the distillation time is 70min, and the distillate is collected for the 2nd-stage distillation. The temperature is 120°C, the pressure is 170Pa, distilled for 60min, the distillate is collected, and the third-stage distillation is carried out. The temperature of the evaporation surface is 60°C, the pressure is 170Pa, and the distillate is collected to obtain 10.0g of gingerol, which is detected by HPLC. The purity is 98.8%.

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Abstract

The invention relates to a method for preparing ginger phenol, which has the characteristics of simple and convenient operation, low pollution and low energy consumption. The method comprises the following process steps of: adding ginger rootstocks into a CO2 supercritical extractor; taking ethyl acetate as an entrainer to obtain an extract; injecting the extract into a molecular still for performing level-3 molecular distillation; and collecting a distillate to obtain the ginger phenol. The method for preparing the ginger phenol has the characteristics of high product purity and easy implementation of industrialization amplification.

Description

technical field [0001] The invention relates to a preparation method of gingerol, in particular to a preparation method of extracting gingerol from plants. Background technique [0002] Gingerol (Shogaol), molecular formula: C 17 h 24 o 3 , Molecular weight: 276.375, CAS accession number: 555-66-8, mainly exists in various plants of Zingiberaceae, among which Zingiber officinale rhizome of Zingiberaceae plant is rich in content, and its molecular formula is as follows: [0003] [0004] Modern studies have shown that gingerol has various pharmacological effects such as antibacterial, anti-inflammatory, cardiotonic, blood lipid lowering, and blood pressure lowering, and it is also a raw material for preparing other important active compounds. [0005] In the prior art, the industrial production process for extracting gingerol is seldom disclosed. Chinese patent document CN101530607A discloses a method for extracting gingerols, but the products are mainly mixtures, and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/255C07C45/82
CPCY02P20/54
Inventor 王峰王琳张发成
Owner SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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