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Method and system for detection of phenotype genes and analysis of biological information

A bioinformatics and genetic technology, applied in biochemical equipment and methods, microbiological measurement/inspection, special data processing applications, etc., can solve problems such as parameter inconsistencies, achieve rapid processing and reduce misleading effects

Active Publication Date: 2011-12-21
BGI TECH SOLUTIONS
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Problems solved by technology

[0003] In the current study, more genes can be detected by comparing the phenotype genes with the whole genome sequence, but due to the inconsistency of the set parameters in the screening, there will be many pseudogenes at the same time

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  • Method and system for detection of phenotype genes and analysis of biological information
  • Method and system for detection of phenotype genes and analysis of biological information
  • Method and system for detection of phenotype genes and analysis of biological information

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Embodiment Construction

[0026] The present invention will be described more fully hereinafter with reference to the accompanying drawings, in which exemplary embodiments of the invention are illustrated.

[0027] figure 1 A flowchart showing a method for detecting phenotypic genes and analyzing biological information provided by an embodiment of the present invention.

[0028] Such as figure 1 As shown, the method 100 for detecting phenotypic genes and analyzing biological information includes: step 102, using the sequence of the target gene to perform local comparisons with the nucleic acid sequences of the genome coding regions predicted by each closely related species, and according to the results of the local comparisons get homologous sequences. For example, the software "BLAST" can be used to locally compare the sequence of the target gene with the nucleic acid sequence of the genome coding region of each closely related species, wherein the reference sequence is the nucleic acid sequence of ...

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Abstract

The invention discloses a method and a system for detection of phenotype genes and analysis of biological information. The method comprises the following steps of: performing local comparison between the sequence of target genes and nucleotide sequences of predicted genome coding regions of all allied species respectively, and obtaining a homologous sequence according to the local comparison results; screening the homologous sequence to obtain the homologous genes; extracting a DNA sequence from the homologous genes, converting the DNA sequence into a protein sequence, performing the overall comparison, and then converting the protein sequence into the DNA sequence; constructing a gene tree for the DNA sequence obtained by conversion, and working out Dn / Ds of each branch; and performing positive selection detection and detecting positive selection loci. The method and the system provided by the invention have the advantages of quickly processing a large amount of data information and discovering more accurate information, reducing misguiding of pseudogenes on analysis of biological information and helping to acquire the biological information to explain more biological problems.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a method and system for detecting phenotype genes and analyzing biological information. Background technique [0002] Gene analysis based on biological phenotype characteristics, including some physiological, biochemical, and behavioral traits, was mainly based on the test of experimental platforms before the emergence of large-scale genomic data. With the development of people's understanding of biology from the macroscopic to the microscopic, the basis for scientists to classify species has also developed from the macroscopic form to the microscopic molecule, and breakthroughs have been made. With the continuous emergence of genome information with a certain genetic relationship, comparative analysis of the sequences between species with a certain blood relationship in the evolution process to obtain the rich information contained in the genome has become a high-throughput and rout...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F19/18C12Q1/68
Inventor 安娜李波
Owner BGI TECH SOLUTIONS
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