Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Method for forming composite rhBMP-2 elasticity modulus graded porous titanium alloy support rod for femoral head and neck

An elastic modulus, rhbmp-2 technology, applied in medical science, prosthesis and other directions, can solve the problems of not taking into account the changing characteristics of the femoral head and neck, affecting the repair and reconstruction of the support rod bone, and the complex preparation process of porous tantalum rods. Achieve stable osteoinductive performance, avoid stress shielding effect, and good osteoconductivity

Inactive Publication Date: 2010-12-08
FOURTH MILITARY MEDICAL UNIVERSITY
View PDF2 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this single porous tantalum rod has certain deficiencies: First, although the porous tantalum rod can play a certain role in structural support, it is not designed in consideration of the biomechanical characteristics of the femoral head and neck, and There are obvious differences in the biomechanical properties (especially the elastic modulus) of the proximal femur in the human body, so that regional stress mismatch will inevitably occur, resulting in a stress shielding effect, which will affect the bone repair and reconstruction around the support rod; the second is porous The tantalum rod is only a single porous metal material, which does not have the activity of inducing osteogenesis. It is difficult to use it to repair the diseased femoral head tissue to play a satisfactory repairing effect. Third, the preparation process of the porous tantalum rod is complicated, and there is no such preparation technology in China. , products are completely dependent on imports

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for forming composite rhBMP-2 elasticity modulus graded porous titanium alloy support rod for femoral head and neck
  • Method for forming composite rhBMP-2 elasticity modulus graded porous titanium alloy support rod for femoral head and neck

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] The present invention will be described in further detail below in conjunction with the accompanying drawings.

[0021] The preparation method of the present invention is as follows:

[0022] 1) Preparation of Porous Titanium Alloy Support Rods with Gradual Elastic Modulus

[0023] Firstly, the titanium alloy powder is prepared by the "electrode induction melting gas atomization method", and then the prepared titanium alloy powder and the pore-forming agent polymethyl methacrylate are mixed and processed to form a powder block by the "cold rolling method". The body is sintered at 1000-1400°C to obtain a porous titanium alloy bulk material. During the production process, according to the measured biomechanical parameters of the femoral head, neck, and rotor, by adjusting the volume ratio of titanium alloy powder to the pore-forming agent polymethyl methacrylate, and the particle size of the pore-forming agent, the Change the porosity and pore size of the material in or...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle size (mesh)aaaaaaaaaa
lengthaaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a method for forming a composite rhBMP-2 elasticity modulus graded porous titanium alloy support rod for the femoral head and the neck. Titanium alloy powder is prepared with an electrode induction melting gas atomization method, and the integrated elasticity modulus graded porous titanium alloy support rod consisting of a head part, a body part and a tail part is prepared according to actually measured biomechanical parameters of the femoral head, the neck and a rotor, wherein the head part and the body part are prepared by sintering the titanium alloy powder and pore-forming agents through the adoption of a cold rolling method, the tail part is prepared by directly sintering the titanium alloy powder, and the porous titanium alloy support rod is immersed in a rhBMP-2 / gelatin controlled release microsphere solution. The product prepared by the method can simulate the biomechanical properties of the femoral head and the neck of a human body to the utmost extent, thereby being beneficial to the stress transfer between materials and bone tissue interfaces, avoiding poor bone restoration caused by the stress shielding effect; and simultaneously, sustained-release microspheres on which bone induced growth factors (rhBMP-2) are loaded endue the materials per se with good bone conductivity.

Description

technical field [0001] The invention relates to a preparation method of a support rod for treating early-stage avascular necrosis of the femoral head, in particular to a construction method of a rhBMP-2 composite rhBMP-2 elastic modulus gradient porous titanium alloy support rod for the neck of the femoral head. Background technique [0002] Avascular necrosis of the femoral head is a common orthopedic disease in young and middle-aged people. As the disease progresses, 60-80% of patients have to undergo total hip arthroplasty due to femoral head collapse, deformation and traumatic arthritis, which causes great losses to the patients themselves, their families and society. Improper or untimely treatment of femoral head necrosis is the main reason for this consequence. At present, there are many methods to prevent early femoral head necrosis and femoral head collapse, mainly including restrictive weight bearing, intramedullary decompression, free fibula transplantation, and s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/54A61L27/56
Inventor 郭征郝玉林李述军樊向利
Owner FOURTH MILITARY MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products