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Rhoifolin and hyperin composition and application of medicines prepared therefrom

A technology of Rhodorin and Hyperoside, which is applied in the field of Rhodorin and Hyperin composition and its preparation of medicines, can solve problems such as undiscovered, and achieve inhibition of replication, reduction of infection, prevention and treatment of influenza and The effect of its complications

Active Publication Date: 2010-12-08
JIANGXI SHANXIANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been found that the round leaves of Shanxiang and the rhoside and hyperin contained in it, the orange red and the rhoside contained in it, Hypericum perforatum and the hyperoside contained in it have the effect of inhibiting influenza virus infection and replication. The role of neuraminidase was not found to inhibit

Method used

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  • Rhoifolin and hyperin composition and application of medicines prepared therefrom
  • Rhoifolin and hyperin composition and application of medicines prepared therefrom
  • Rhoifolin and hyperin composition and application of medicines prepared therefrom

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Rhodorin and hyperin compositions of the present invention, wherein the molecular formula of rhodorin: C 27 h 30 o 14 , Molecular weight: 578.52, the structural formula of described Rhodorin is as follows:

[0031]

[0032] The molecular formula of the hyperin: C 21 h 20 o 12 , Molecular weight: 464.38, the structural formula of described hyperoside is as follows:

[0033]

[0034] Take 1,000g of the leaves of Cyperus japonica, add 12 times the amount of 70% ethanol for reflux extraction for 2 hours, filter, add 10 times the amount of 70% ethanol for reflux extraction for 1.5 hours, filter, combine the two extracts, recover the ethanol, and pass the aqueous solution through the The treated D101 macroporous resin column was eluted with water, 10% ethanol, 45% ethanol, and 1% sodium hydroxide solution respectively, and the eluted part of 45% ethanol was collected, concentrated under reduced pressure, and dried to obtain more than 30% rhodium, The mixed total g...

Embodiment 2

[0037]Take 100000g of Huajuhong, add 12 times the amount of 70% ethanol for reflux extraction for 2 hours, filter, add 10 times the amount of 70% ethanol for reflux extraction for 1.5 hours, filter, combine the two extracts, recover ethanol, and pass the aqueous solution through the treated A good D101 macroporous resin column was eluted with water, 10% ethanol, 45% ethanol, and 1% sodium hydroxide solution respectively, and the eluted part of 45% ethanol was collected, concentrated under reduced pressure, and dried to obtain more than 30% rhodium The mixed total glycosides were separated by silica gel column chromatography and Sephadex LH-20 column chromatography, and the rhoradiside fractions were combined and crystallized to obtain the pure rhodoside (450g, purity: 98.9%). UV, IR, ESI-MS, 1 H-NMR, 13 Compared with C-NMR, the structure of Rhodorin was determined.

Embodiment 3

[0039] Take 100000g of Huajuhong, add 10 times the amount of 60% ethanol for reflux extraction for 2 hours, filter, add 8 times the amount of 60% ethanol for reflux extraction for 1.5 hours, filter, combine the two extracts, recover ethanol, and pass through the treated A good D101 macroporous resin column was eluted with water, 10% ethanol, 45% ethanol, and 1% sodium hydroxide solution respectively, and the eluted part of 45% ethanol was collected, concentrated under reduced pressure, and dried to obtain more than 30% rhodium The mixed total glycosides were separated by silica gel column chromatography and Sephadex LH-20 column chromatography, and the rhoradiside fractions were combined and crystallized to obtain the pure rhodoside (455g, purity: 98.6%). UV, IR, ESI-MS, 1 H-NMR, 13 Compared with C-NMR, the structure of Rhodorin was determined.

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Abstract

The invention relates to a rhoifolin and hyperin composition which is a composition prepared from 20%-80% of rhoifolin and 80%-20% of hyperin in percentage by weight. The composition can be used as a neuraminidase inhibitor for preventing and treating flu and can be made into pharmaceutically acceptable formulations.

Description

technical field [0001] The invention relates to a rhoin and hyperin composition and its use for preparing medicines. Background technique [0002] At present, influenza virus is becoming more and more serious, and influenza virus is closely related to respiratory diseases and systemic diseases caused by it. my country is one of the countries with high incidence of influenza. Not only has a large population, but also living habits are conducive to the transmission of influenza virus. The average number of episodes ranged from 0.3 to 0.7, and 2 to 4 in key groups. Influenza poses a serious threat to human beings, especially the emerging strains of influenza virus, which not only cause secondary infections of other microorganisms, but also directly lead to organ damage and allergic reactions leading to death. But there is no effective method and treatment means for treating influenza virus and its disease (influenza) at present, such as treating the inflammatory response for cl...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P31/16A61P13/12A61P1/00A61P11/00C07H17/07C07H1/08
Inventor 杨小玲谢宁王燕平叶劲英李志勇吕武清刘地发程帆蔡永红
Owner JIANGXI SHANXIANG PHARMA
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