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Method for preparing pseudo-ginseng flower extract

A technology of Panax notoginseng flower and extract, applied in the field of preparation of Panax notoginseng flower extract, can solve the problems of harsh conditions, application restrictions and the like, and achieves the effect of simple purification method conditions and favorable industrialization promotion and application.

Active Publication Date: 2010-11-17
SHANGHAI SINE PROMOD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method can prepare Panax notoginseng flower extract with a total saponin content of 50% to 100%, but the conditions of this method are relatively harsh, and the extraction solvent is limited to 50% to 80% ethanol, and the type of macroporous resin is AB-8 resin, so that the application of this method is limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Panax notoginseng 1000g, decoct twice with water, 10000ml each time, combine the water extract, concentrate the film to a relative density of 1.10, add 10000ml of water to stir and dilute, put it on a D-101 macroporous resin column, and then use water, 20% ethanol, 40% Elution with ethanol and 90% ethanol, combined 20% ethanol eluate and 40% ethanol eluate, concentrated under reduced pressure and evaporated to dryness, pressure -0.1Mpa, temperature 80°C, to obtain 110.5g of Panax notoginseng flower extract, yield 11.1 %, its total saponin content detected by ultraviolet spectrophotometry is 71.2%.

Embodiment 2

[0022] Panax notoginseng flower 1000g, add 80% ethanol and decoct 3 times, 8000ml each time, combine extracts, concentrate under reduced pressure, pressure -0.1Mpa, temperature 70℃, to relative density 1.20, add 6000ml water, stir and dilute, add HPD-450 and H-103 macroporous resin column mixed in a ratio of 3:1, eluted with water, 30% ethanol, 70%, 90% ethanol in sequence, collected 70% ethanol eluate, concentrated under reduced pressure, pressure -0.1Mpa, temperature 80 ℃, and evaporated to dryness to obtain 134.2 g of Panax notoginseng flower extract, with a yield of 13.4%. The total saponin content was 73.1% as detected by ultraviolet spectrophotometry.

Embodiment 3

[0024] Panax notoginseng flower 1000g, add 30% ethanol and decoct twice, 16000ml each time, combine the extracts, concentrate under reduced pressure, pressure -0.1Mpa, temperature 80℃, until the relative density is 1.20, add 8000ml of water, stir and dilute, then put on ADS-17 Hole resin column, eluted successively with water, 30% ethanol, 60%, 90% ethanol, collected 60% ethanol eluate, concentrated under reduced pressure and evaporated to dryness, pressure -0.1Mpa, temperature 80°C, to obtain Sanqihua extract 134.7 g, the yield is 13.5%, and the total saponin content detected by ultraviolet spectrophotometry is 50.1%.

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PUM

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Abstract

The invention provides a method for preparing a pseudo-ginseng flower extract, which comprises the following steps of: extracting by using solution of water and ethanol, adding water after concentration, feeding in a macroporous resin column, collecting ethanol elution liquid, concentrating and drying, and the like. The total saponin content in the obtained pseudo-ginseng flower extract is 50 to 95 percent. The extraction and purification method has simple and convenient conditions, and is favorable for industrialized popularization and application.

Description

technical field [0001] The invention relates to traditional Chinese medicine, in particular to a preparation method of Sanqi flower extract with antihypertensive activity. Background technique [0002] Panax notoginseng is the dried flower buds of the traditional Chinese medicine Sanqi (Flower buds of Panax notoginseng (Burk) F.H.Chen). According to the "Dictionary of Chinese Medicine": Panax notoginseng has the characteristics of sweet and cool, heat-clearing, calming the liver, and can be used to lower blood pressure and treat Dizziness, dizziness, tinnitus, etc., folks often drink tea to treat high blood pressure and pharyngitis. [0003] Modern chemical research shows that Panax notoginseng contains saponins, polysaccharides, amino acids and various trace elements, and the saponins mainly include ginsenosides Rb1, Rb2, Rb3, Rc, Rd and Panax notoginseng saponins D, O, P, Q, S, T and other panaxadiol type saponins. Modern pharmacological and clinical studies have shown t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P9/12A61P11/04A61P9/06A61K133/00
Inventor 胡林森林君王佑华聂恒楼丹飞
Owner SHANGHAI SINE PROMOD PHARMA
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