Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Genetic markers for horned and polled cattle and related methods

A marker, associated technology, applied to genetic markers of horned and hornless cattle and related fields

Inactive Publication Date: 2010-11-10
ZOETIS SERVICE LLC
View PDF28 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no researcher has done an effective and accurate test for all herds

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Genetic markers for horned and polled cattle and related methods
  • Genetic markers for horned and polled cattle and related methods
  • Genetic markers for horned and polled cattle and related methods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Example 1 : Identification of genetic markers associated with horned / hornless phenotypes in dairy cows

[0110] Georges et al. used microsatellite markers in 1993 to locate the hornless mutation in Jersey cows at the proximal end of bovine chromosome 1 (BTA01). More recent work has refined the mapping of the hornless locus, including mapping of microsatellite markers (Schmutz et al. 1995; Brenneman et al. 1996; Harlizius et al. 1997; 2005) and the creation of a BAC-based physical map of the hornless regions of chromosomes (Wunderlich et al 2006). The chromosomal positions of the near-central gene ATP5O and the most distal gene KRTAP8 in the hornless region of the chromosome are equivalent to those of the published bovine genome compilation version 3.1 (www.hgsc.bcm.tmc.edu / projects / bovine / ) compared with the referenced resources 0.6Mb and 3.9Mb.

[0111] The aim of this work was to identify single nucleotide polymorphisms (SNPs) associated with the hornless trait by...

Embodiment 2

[0121] Example 2 : Using single nucleotide polymorphisms to improve offspring characteristics

[0122] To improve the average genetic merit of a defined trait in a population, one or more markers with a clear association with that trait can be used in the selection of breeding animals. In the case of each locus discovered, using animals with marker alleles (or haploids of multiple marker alleles) that are in population-wide linkage disequilibrium with the desired phenotype, over time Shifting increases the frequency of the allele (and phenotype) in the population, thereby increasing the average genetic merit of the trait in the population. This increased genetic advantage can be propagated to commercial populations to fully realize its value.

[0123] For example, a DNA testing program protocol or the production of semen through the use of DNA markers as described herein can greatly alter the frequency of the hornless allele in a given population. Testing bull semen in a p...

Embodiment 3

[0137] Example 3 : Identification of SNPs

[0138] A nucleic acid sequence contains a SNP of the present invention if the nucleic acid sequence contains at least 20 consecutive nucleotides comprising and / or adjacent to the polymorphisms described in Tables 1 and 2 and the Sequence Listing. Alternatively, in cases where the shorter contiguous nucleotide sequence is unique in the bovine genome, the polymorphism described in Tables 1 and 2 and the Sequence Listing or adjacent to the shorter contiguous Nucleotide fragments to identify the SNPs of the present invention. Typically, a SNP site is characterized by a consensus sequence comprising a polymorphic site therein, the position of the polymorphic site, and the various alleles at the polymorphic site. "Consensus sequence" refers to a DNA sequence constructed to be identical at each nucleotide position of an aligned cluster of sequences. These clusters are commonly used to identify SNPs and Indel (insertion / deletion) polymor...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Embodiments of the present invention provide methods for improving desirable animal traits including the horned / polled phenotype in bovine animals. Also provided are methods for determining a dairy animal's genotype with respect to multiple markers associated with polled, fitness and / or productivity traits. The invention also provides methods for selecting or allocating animals for predetermined uses such as progeny testing or nucleus herd breeding, for picking potential parent animals for breeding, and for producing improved progeny animals. Also provided are methods for identifying genetic markers associated with polled, fitness and / or productivity traits that are in allelic association with the SNPs disclosed herein.

Description

[0001] priority statement [0002] This application claims the benefit of US Provisional Application No. 60 / 977,239, filed October 3, 2007, which is hereby incorporated by reference in its entirety. [0003] Introduction of Sequence Listing [0004] The sequence listing is contained in a file named "Polled_v2_ST251_final.txt". The file size is 55,296 bytes (54kb) (identified by MS-Windows XP), contains 148 sequences, and was generated on September 19, 2008. Enclosed herewith, incorporated by reference. technical field [0005] The present invention relates to the enhancement of desirable properties in cattle. More specifically, the present invention relates to the use of genetic markers in methods of improving the horned / hornless phenotype in cattle. Background technique [0006] The viability and competitiveness of the future cattle industry, specifically the dairy industry, depends on the continuous improvement of animal phenotypes. While many traits already have some...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6888C12Q2600/124C12Q2600/156C12Q2600/158
Inventor 爱德华·J·卡吉尔迈克尔·D·格罗斯尼古拉斯·J·尼辛格
Owner ZOETIS SERVICE LLC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com