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Technical method for extracting active component from Chinese herbal medicine

A process method and technology of Chinese herbal medicine, applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, plant/algae/fungus/moss components, etc., can solve the problem of large amount of ethanol solvent, slow elution time, and incomplete elution, etc. problem, to achieve the effect of solving inability to elute, complete desorption, simple separation and acquisition

Inactive Publication Date: 2012-07-11
HUBEI CHINA TOBACCO IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of the macroporous resin adsorption method is that the amount of ethanol solvent is large, the elution time is slow, and the elution cannot be completed.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: Extraction of Puerarin in Pueraria Radix Extract

[0025] Weigh 300g of kudzu root, add 900g of 70% alcohol for extraction, concentrate the solution to less than 300g, add it to 500g of resin, let it absorb for 3 hours, elute with 1500g of water, and drain the macroporous resin. Put the treated macroporous adsorption resin in a supercritical extraction kettle for supercritical carbon dioxide extraction. The extraction pressure is 8MPa, the extraction temperature is 40°C, the separation pressure is 8MPa, the separation temperature is 30°C, and the weight of the raw material is 10%. 95% ethanol was used as entrainer, the flow rate of carbon dioxide was controlled to be 30Kg / h, and the extraction time was 1h. The content of puerarin in the extract reached 67% after removal of the solvent.

Embodiment 2

[0026] Embodiment 2: Extraction of total flavonoids in hawthorn

[0027] Weigh 200g of hawthorn, add 800g of water to extract, concentrate the solution to about 400g, add to 600g of resin, let it absorb for 4 hours, elute with 2400g of water, and drain the macroporous resin. The treated macroporous adsorption resin is placed in a supercritical extraction kettle for supercritical carbon dioxide extraction. Choose 12MPa for the extraction pressure, 45°C for the extraction temperature, 8MPa for the separation pressure, 40°C for the separation temperature, 95% ethanol which accounts for 15% of the weight of the macroporous adsorption resin as the entrainer, control the flow rate of carbon dioxide to 20Kg / h, and the extraction time It is 1.5h. The content of total flavonoids in the extract reaches 72%.

Embodiment 3

[0028] Embodiment 3: Extraction of baicalin in Scutellaria baicalensis

[0029] Weigh 200g of Scutellaria baicalensis, add 1600g of 60% alcohol for extraction, concentrate the solution to less than 300g, add it to 500g of resin, let it absorb for 6 hours, elute with 2500g of water, and drain the macroporous resin. The treated macroporous adsorption resin is placed in a supercritical extraction kettle for supercritical carbon dioxide extraction. Choose 20MPa for the extraction pressure, 50°C for the extraction temperature, 9MPa for the separation pressure, 45°C for the separation temperature, 95% ethanol which accounts for 20% of the weight of the macroporous adsorption resin as the entrainer, control the flow rate of carbon dioxide to 50Kg / h, and the extraction time for 3h. The content of baicalin in the extract reaches 52%.

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PUM

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Abstract

The invention discloses a technical method for extracting an active component from Chinese herbal medicine. The technical method includes the following steps: (1) using solvent to extract the Chinese herbal medicine to obtain extract; (2) concentrating the extract to obtain concentrated liquor; (3) using macroporous absorption resin to enrich the active traditional Chinese medicine component of the concentrated liquor; (4) under the supercritical condition, using supercritical fluid to sufficiently contact with the macroporous absorption resin, removing organic micromole residue, separating the liquor from the macroporous absorption resin under the liquid state of the supercritical fluid, and relieving the high pressure of the liquor, so that the active component of the Chinese herbal medicine is obtained. The invention has the advantages of less solvent dosage, short elution time, complete elution and the like.

Description

technical field [0001] The invention relates to a process for extracting effective components of traditional Chinese medicine, specifically a process for first enriching the active components of traditional Chinese medicine with macroporous adsorption resin, and then eluting with supercritical fluid to obtain the effective components of traditional Chinese medicine. Background technique [0002] Macroporous adsorption resin is a porous and spongy thermosetting polymer with a three-dimensional structure. It can selectively adsorb organic molecules by relying on the Van der Waals force between it and the adsorbed molecules (adsorbates), and is a good method for separating water-soluble Chinese herbal medicines. An effective approach to ingredients. The extraction agent used in supercritical extraction is supercritical fluid, which is a state between gas and liquid that is neither gaseous nor liquid. This substance can only be extracted when its temperature and pressure exceed ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/00A61K36/48A61K36/539A61K36/734A61K36/752
Inventor 王萍张敦铁喻世涛
Owner HUBEI CHINA TOBACCO IND
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