2-(substituted phenyl)-2-(4,5,6,7-thiophane[3,2-c] pyridine-5(4H)-group)-n-substitute-acetamide as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of malignant tumor resistant medicaments and provides 2-(substituted phenyl)-2-(4,5,6,7-thiophane[3,2-c] pyridine-5(4H)-group)-N-substitute-acetamide with a structure of a general formula I and a pharmaceutically acceptable salt thereof, wherein R is hydrogen, a C1-C3 straight chain or a branched alkyl group; and R1 and R2 are hydrogen, C1-C3 straight chains or branched alkyl groups, halogens, halogenated methyl groups and C1-C3 alkoxyl groups. The invention also relates to a preparation method of the compound and also discloses a medical composition using the compound or the pharmaceutically acceptable salt thereof as an active and effective constituent and application thereof as malignant tumor resistant medicaments.

Description

technical field The invention belongs to the technical field of medicine, more specifically, relates to a class of 2-(substituted phenyl)-2-(4,5,6,7-tetrahydrothieno[3,2- c] Pyridin-5(4H)-yl)-N-substituted-acetamides and processes for their preparation. Background technique Cancer is one of the most important killers of human health, and its death rate ranks first in my country and second in the world. According to the statistics of the World Health Organization, the number of cancer deaths in the world in 2007 reached 7.9 million (accounting for about 13% of all deaths), and lung cancer, gastric cancer, liver cancer, colon cancer and breast cancer are the main culprits of most cancer deaths every year. In recent years, the incidence of cancer has been increasing year by year due to the increasing risk of cancer risk factors such as urban air pollution, overweight or obesity, alcohol and tobacco abuse. In developing countries, as deaths from infectious diseases and child m...

AI Technical Summary

Problems solved by technology

At present, there are hundreds of anti-cancer drugs clinically, which can effectively prolong the life of cancer patients or improve the quality of life of cancer patients, but most of the drugs are cytotoxic drugs with low selectivity. At the same time, it also has serious damage to normal cells, causing strong toxic and side effects, and there is a problem of drug resistance

In addition, the existing chemical drugs are not ideal for the treatment of most solid tumors

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