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Arginine (s)-ibuprofen granules and preparation method thereof

A technology of dextro-ibuprofen and arginine, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. preparations, failure to cover up the irritating odor of drugs, and easy deliquescence of arginine ibuprofen tablets, achieving the effects of rapid dissolution, low cost and good solubility

Active Publication Date: 2012-07-04
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The Chinese patent application with publication number CN101390844A discloses a kind of arginine ibuprofen tablet and preparation method thereof. Inconvenience, especially for children with medication inconvenience
[0007] Chinese patent CN200310108031.0 discloses a method for preparing granules containing ibuprofen arginine composition, wherein a coating step is adopted to overcome the shortcoming of ibuprofen arginine easy to absorb moisture, and to cover up the stimulation of the drug itself Sexual smell, but more steps of coating than general granules, long production cycle and high cost
However, there are no relevant reports on arginine-dextroibuprofen preparations

Method used

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  • Arginine (s)-ibuprofen granules and preparation method thereof
  • Arginine (s)-ibuprofen granules and preparation method thereof
  • Arginine (s)-ibuprofen granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Pass arginine dextrobuprofen and hypromellose K4M through 80-mesh sieve respectively, sucrose is crushed and passed through 80-mesh sieve, and set aside.

[0062] Weigh the raw materials of the following prescription quantities:

[0063] Dexibuprofen Arginine 1.85kg

[0064] Sucrose 37.65kg

[0065] Hypromellose K4M 0.5kg

[0066] 1% hypromellose K4M 50% ethanol aqueous solution 2.5kg

[0067] Lychee essence 2.4kg.

[0068] Thoroughly mix Dexibuprofen Arginine, Hypromellose K4M, and Lychee Flavor to obtain a mixture. Divide sucrose into 3 parts of equal weight, add the above mixture in 3 times, and mix after each addition. 10 minutes, then add 1% hypromellose K4M50% ethanol aqueous solution (referring to the solution that hypromellose K4M is dissolved in the ethanol aqueous solution of 50% concentration by volume, wherein, hypromellose The mass percent concentration of K4M is 1%) to make soft material, adopt 16 mesh sieves to granulate and then dry at 60 DEG C for ...

Embodiment 2

[0070] Pass arginine dextrobuprofen and povidone K30 through an 80-mesh sieve respectively, and sucrose is crushed and passed through an 80-mesh sieve for later use.

[0071] Weigh the raw materials of the following prescription quantities:

[0072] Dexibuprofen Arginine 2.5kg

[0073] Sucrose 68.36kg

[0074] Povidone K30 0.82kg

[0075] 95% ethanol aqueous solution 3.8kg

[0076] Aspartan 4.6kg.

[0077] Fully mix arginine dextrobuprofen, povidone K30, and aspartame to obtain a mixture. Divide sucrose into 3 parts of equal weight, add the above mixture in 3 times, and mix after each addition. 10 minutes, then add 95% (volume percent concentration) ethanol aqueous solution to make soft material, use 16 mesh sieve to granulate, and blow dry at 80 ℃ for 1 hour, adopt 14 mesh sieve to obtain dextrorotatory arginine after granulation After the ibuprofen granules and intermediates pass the inspection, they are divided into 198800 bags by 400 mg / bag in aluminum-plastic composi...

Embodiment 3

[0079] Pass arginine dextrobuprofen and povidone K30 through 80-mesh sieve respectively, mannitol is crushed and pass through 80-mesh sieve, and set aside.

[0080] Weigh the raw materials of the following prescription quantities:

[0081] Dexibuprofen Arginine 3kg

[0082] Mannitol 73.90kg

[0083] Povidone K30 0.9kg

[0084] 95% ethanol aqueous solution 4.5kg

[0085] Stevioside 4.2kg.

[0086] Fully mix arginine dextrobuprofen, povidone K30, and stevioside to obtain a mixture, divide mannitol into 3 parts of equal weight, add the above mixture in 3 times, and mix for 10 minutes after each addition. Minutes, then add 95% (volume percentage concentration) ethanol aqueous solution to make soft material, use 16 mesh sieve to granulate and then blow dry at 65 ℃ for 2.5 hours, adopt 14 mesh sieve to obtain arginine dextrorotatory After the ibuprofen granules and intermediates pass the inspection, they are divided into 215,900 bags by 400 mg / bag in aluminum-plastic composite ...

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Abstract

The invention discloses arginine (s)-ibuprofen granules which are prepared from the following raw materials in parts by weight: 1 part of arginine (s)-ibuprofen, 1-100 parts of fillers, 1-20 parts of adhesives, 0.2-10 parts of thickening agents and 0.1-10 parts of flavoring agents. The granules are quickly dissolved in water to form transparent liquid with good mouthfeel, are convenient to take and have high bioavailability. The preparation method is simple, dispenses with any special equipment and is suitable for industrial production.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an arginine-dextroibuprofen granule and a preparation method thereof. Background technique [0002] Ibuprofen, chemical name: 2-methyl-4-(2-methylpropyl) phenylacetic acid, IUPAC name: 2-(4-isobutylphenyl) propanoic acid, CAS No.15687-27-1, molecular formula C 13 h 18 o 2 , with a molecular weight of 206.28, is a non-steroidal anti-inflammatory drug (NSAID). It is the first profen drug used clinically and is still widely used in the world. It is recognized as one of the safest drugs in non-steroidal anti-inflammatory drugs. 1. It has analgesic, anti-inflammatory and antipyretic effects. Its mechanism of action is to reduce the synthesis of prostaglandins by inhibiting cyclooxygenase, thereby reducing tissue congestion and swelling caused by prostaglandins, and reducing the sensitivity of peripheral nerve pain. Sex, and play an antipyretic effect through the hypothal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/205A61K47/38A61K47/36A61K47/32A61P29/00A61K31/192A61K31/198
Inventor 刘全国
Owner HAINAN HULUWA PHARMA GRP CO LTD
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