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Preparation method of calcium phosphate ceramics/chitosan-hydroxyapatite composite coating porous material

A technology of hydroxyapatite and calcium phosphorus ceramics, which is applied in coatings, medical science, prostheses, etc., can solve the problems of long preparation period, low mechanical properties of composite materials, and unstable process, so as to improve surface biological activity, Good overall performance, wide range of effects

Inactive Publication Date: 2010-09-15
SUZHOU PULIN BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The porous scaffold prepared by composite nano-hydroxyapatite and chitosan, on the basis of maintaining good biological properties, the strength and toughness of the material have been improved to a certain extent, but there are still problems such as unstable process, long preparation cycle and composite materials. Low mechanical properties and other deficiencies

Method used

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  • Preparation method of calcium phosphate ceramics/chitosan-hydroxyapatite composite coating porous material
  • Preparation method of calcium phosphate ceramics/chitosan-hydroxyapatite composite coating porous material
  • Preparation method of calcium phosphate ceramics/chitosan-hydroxyapatite composite coating porous material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take by weighing chitosan accounting for 1% of the total mass of the solution and dissolve it in an acetic acid solution with a mass concentration of 1%, to make a chitosan-acetic acid solution;

[0028] The mass ratio of hydroxyapatite and chitosan is 2: 1 to take nano-hydroxyapatite powder;

[0029] Adding the nano-hydroxyapatite powder into the chitosan-acetic acid solution, fully stirring to obtain the chitosan-hydroxyapatite suspension;

[0030] Slowly immerse the porous calcium phosphorus ceramics with a pore size of 300-600 μm and a network pore structure into the chitosan-hydroxyapatite suspension, and then slowly lift it out after being fully immersed, and centrifuge at 400 rpm in a centrifuge , to remove excess suspension;

[0031] After the coated porous material is dried, it is put into a glutaraldehyde solution with a mass concentration of 0.25% and the crosslinking agent solution is crosslinked for 3 hours, and then cleaned with absolute ethanol to obtain...

Embodiment 2

[0034] Take by weighing chitosan accounting for 5% of the total mass of the solution and dissolve it in the acetic acid solution whose mass concentration is 3%, to make the chitosan-acetic acid solution;

[0035] The mass ratio of hydroxyapatite and chitosan is 1: 1 to take nano-hydroxyapatite powder;

[0036] Adding the nano-hydroxyapatite powder into the chitosan-acetic acid solution, fully stirring to obtain the chitosan-hydroxyapatite suspension;

[0037] Slowly immerse the porous calcium phosphorus ceramics with a pore size of 300-600 μm and a network pore structure into the chitosan-hydroxyapatite suspension, and then slowly lift it out after being fully immersed, and centrifuge it in a centrifuge at 500 rpm , to remove excess suspension;

[0038] After the coated porous material is dried, it is put into a glyoxal solution with a mass concentration of 1.5% and the cross-linking agent solution is cross-linked for 14 hours, and then cleaned with absolute ethanol to obtain...

Embodiment 3

[0040]Take by weighing chitosan accounting for 3% of the total mass of the solution and dissolve it in the acetic acid solution whose mass concentration is 5%, to make chitosan-acetic acid solution;

[0041] The mass ratio of hydroxyapatite and chitosan is 3: 5 to take nanometer hydroxyapatite powder;

[0042] Adding the nano-hydroxyapatite powder into the chitosan-acetic acid solution, fully stirring to obtain the chitosan-hydroxyapatite suspension;

[0043] Slowly immerse the porous calcium-phosphorus ceramics with a pore size of 300-600 μm and a network pore structure into the chitosan-hydroxyapatite suspension, and then lift it out slowly after being fully immersed, and centrifuge at 450 rpm in a centrifuge , to remove excess suspension;

[0044] After the coated porous material is dried, it is put into a formaldehyde solution with a mass concentration of 2.5% and cross-linking agent solution for cross-linking treatment for 24 hours, and then cleaned with absolute ethanol...

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Abstract

The invention provides a method for preparing a calcium phosphate ceramics / chitosan-hydroxyapatite composite coating porous material, which comprises steps of: selecting porous calcium phosphate ceramics with hole size of 300-600 microns and of a net-shaped hole structure, adding nano-hydroxyapatite in chitosan acetum with the mass percent of 0.5-5 percent to prepare a suspension, coating the surface of the porous calcium phosphate ceramics, and carrying out crosslinking process to obtain the calcium phosphate ceramics / chitosan-hydroxyapatite composite coating porous material, wherein the mass ratio of the hydroxyapatite to the chitosan in the chitosan-hydroxyapatite suspension is (6-1):(1-5). The invention has the technical scheme that a chitosan-hydroxyapatite coating is prepared on the porous calcium phosphate ceramics, thereby enhancing the surface bioactivity of the porous material; the coating is an organic-inorganic composite material and integrates the advantages of the chitosan and the hydroxyapatite, and the constitution of the surface of the material can be conveniently adjusted according to the actual need, thereby endowing the porous material with better combination property.

Description

technical field [0001] The invention relates to a manufacturing process of an organic-inorganic composite porous bone repair material applied in the field of biomedicine, in particular to a method for preparing a calcium phosphorus ceramic / chitosan-hydroxyapatite composite coating porous material. Background technique [0002] At present, in bone defect repair, bone regeneration mainly proceeds through three basic mechanisms, namely osteoconduction, osteogenesis and osteoinduction. Osteoconduction refers to the crawling growth of new bone tissue along the surface or pores of biocompatible materials, which mainly occurs at the contact point between the material and the host bone, and its osteogenesis is limited. Osteoconductive materials only provide biocompatibility for the migration of new bone tissue. interface; osteogenesis refers to the process of directional differentiation of osteogenic stem cells in the defect site on the bioactive surface and induces bone regeneratio...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/12A61L27/56
Inventor 董寅生顾明泽
Owner SUZHOU PULIN BIO TECH
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