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Preparation of calotropis gigantea leaf extract and application of antineoplastic medicament

The technology of leaf extract and croissant melon is applied in the field of preparation and application of antitumor drugs, and achieves the effects of convenient extraction, simple operation and low cost

Inactive Publication Date: 2010-09-15
黄惠民 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These patents are all based on the root of the horned melon, and do not involve the research and application of the leaves of the horned melon. There has been no literature report or patent disclosure about the application of the extract of the horned melon leaf in the preparation of anti-tumor drugs.

Method used

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  • Preparation of calotropis gigantea leaf extract and application of antineoplastic medicament
  • Preparation of calotropis gigantea leaf extract and application of antineoplastic medicament
  • Preparation of calotropis gigantea leaf extract and application of antineoplastic medicament

Examples

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Effect test

Embodiment 1

[0019] a. One-time extraction

[0020] Take 5.0Kg of dried horned melon leaves as raw material, 40.0Kg of n-hexane as the extraction solvent, place the horned melon leaves in an extraction tank after being pulverized, and reflux extraction with the extraction solvent for 3 times, 2 hours / time, and the extract is recovered under reduced pressure After n-hexane, disperse the extract in water to form a suspension, then extract it with dichloromethane organic solvent, and concentrate the remaining aqueous solution to obtain the Ceratia melon leaf extract A with the active component of cardiac glycosides.

[0021] b. Secondary extraction

[0022] Extract the above-mentioned medicinal dregs with 30.0Kg of methanol twice, 2 hours each time, and recover the methanol from the extract under reduced pressure to obtain the Ceratia melon leaf extract B with the active component of cardiac glycosides.

[0023] c. Preparations

[0024] Add appropriate amount of starch and microcrystalline ...

Embodiment 2

[0026] a. One-time extraction

[0027] Take 2.5Kg of dried horned melon leaves as a raw material, 20.0Kg of methanol as an extraction solvent, place the horned melon leaves in an extraction tank after being crushed, and use the extraction solvent to reflux and extract twice, 2 hours each time, and the extract is decompressed to recover methanol Finally, the extract is dispersed in water to form a suspension, and then extracted with n-hexane, and the remaining aqueous solution is concentrated to obtain the extract A of the leaf of the horned melon with the active component of cardiac glycosides.

[0028] b. Preparations

[0029] Add appropriate amount of lactose and sodium carboxymethyl starch to the above-mentioned ox horn melon leaf extract A which has the active component of cardiac glycosides, mix well, make 1000 capsules with povidone K30, dry and size the capsules and put them into capsules.

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Abstract

The invention discloses preparation of a calotropis gigantea leaf extract and application of an antineoplastic medicament. The preparation of the calotropis gigantea leaf extract is characterized by comprising the following steps of: using calotropis gigantea leaves as a raw material; extracting and concentrating the raw material to obtain the calotropis gigantea leaf extract comprising cardiac glycoside active constituents; and according to the conventional preparation process, preparing the extract into tablets, capsules, granules, dripping pills, oral liquid or injections applied in the antineoplastic medicament. Compared with the prior art, the preparation has the advantages of convenient extraction of an antineoplastic active substance, simple operation, low cost and significant antineoplastic curative effect, and provides a new medicament for treating tumors.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to the preparation of a horned melon leaf extract and the application of antitumor drugs. Background technique [0002] The leaves of Calotropis gigantea L. are the leaves of Calotropis gigantea L. in the family Asclepiadaceae. There are about 6 species of Ceratia genus, which are widely distributed in tropical and subtropical regions of Asia and Africa. my country abounds in two of them, one is Calotropis gigantea I., which is distributed in Hainan, Guangdong, Sichuan and Yunnan, and the other is Calotropis gigantea L., which is sporadically distributed in Guangdong, Guangxi and Yunnan. [0003] Ceratia genus plants have extensive medicinal value among the people. Its roots, stems, leaves, fruits, and white juices from various parts can be used medicinally. Treatment of asthma, cough, leprosy, ulcers, hemorrhoids, tumors and other diseases. Foreign scholars ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/27A61K9/20A61K9/48A61K9/16A61K9/00A61P35/00A61K127/00
Inventor 黄惠民王玉芹肖繁花
Owner 黄惠民
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