Application of insect small-molecule active substance in preparing antiatherosclerotic medicine

Abstract

The invention discloses an application of an insect small-molecule active substance in preparing an antiatherosclerotic medicine. The insect small-molecule active substance of the invention is prepared by the method comprising the following steps: (1) feeding adult flies, attracting the adult flies to spawn, feeding larvae with feed, and removing feed residues; (2) carrying out cold and hot stimulus induction on the larvae; and (3) after inducing for 48h, collecting the larvae, cleaning, disinfecting, breaking polypide cells, homogenizing at high speed, centrifugating, separating supernate, ultrafiltering, and obtaining the insect small-molecule active substance of which the molecular weight is less than 30KD after the filtrate is subject to freeze drying. The purely natural insect small-molecule active substance of the invention can effectively reduce the serum inflammatory factors and adjust the blood fat, promotes cholesterol efflux of macrophage, has an oxidation-resisting efficacy, and can be applied in a plurality of the fields of medical treatment, feed processing, food industry and the like.

Description

technical field [0001] The invention relates to the field of insect active substances, in particular to the application of insect small molecule active substances with a molecular weight less than 30KD in the preparation of anti-atherosclerosis drugs. Background technique [0002] The scientific name of the housefly is Musca domestica Linnaeus, belonging to the class Insecta, order Diptera, family Muscaidae. As early as the Ming Dynasty, housefly larvae were used clinically to treat pustules, boils, and bacterial infections of the digestive organs. In recent years, they have been widely used in the treatment of various traumas. [0003]For the theory of lipid metabolism disorder and lipid infiltration in the pathogenesis of atherosclerosis (Szypula I, Kotulska A, Szopa M, Pieczyrak R, Kucharz EJ. Adiposis dolorosa with hypercholesterolemia and premature severe generalized atherosclerosis. Wiad Lek.2009; 62 (1): 64-5.), oxidative damage theory (Dimitrova-Shumkovska J, Veenma...

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Problems solved by technology

Vitamin C, E and β-carotene are often used in antioxidant therapy, but their antioxidant capacity is weak; synthetic probucol has better antioxidant effect, but there are side effects such as gastrointestinal tract and heart discomfort (Yamashita S , Matsuzawa Y. Where are we with probucol: a newlife for an old drug? Atherosclerosis. 2009; 207(1): 16-23.)

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