C-aryl glucoside derivative, preparation method thereof and application thereof in medicine

Abstract

The invention relates to a C-aryl glucoside derivative shown by a formula (I) or salts thereof acceptable in pharmacy or all stereoisomerides thereof, a preparation method thereof, a pharmaceutical composition containing the derivative, and the application of the derivative as a therapeutic agent, particularly as a SGLT (Sodium Dependent Glucose Transporter) inhibitor, wherein the definitions of each substituent group in the formula (I) are same with those in a specification.

Description

Technical field The present invention relates to a C-aryl glucoside derivative represented by the general formula (I) or a pharmaceutically acceptable salt or all stereoisomers thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative, And its use as a therapeutic agent, especially as a sodium-dependent glucose transporter (SGLT) inhibitor. Background technique Diet therapy and exercise therapy are two essential methods of treating diabetes. When these therapies are insufficient to control the disease, insulin or oral hypoglycemic drugs can be used. At present, biguanide compounds, sulfonylurea compounds, insulin resistance improvers and α-glucosidase inhibitors have been used as hypoglycemic agents. However, these hypoglycemic drugs have various side effects. For example, biguanide compounds can easily cause lactic acidosis, sulfonylurea compounds can cause significant hypoglycemia, insulin resistance improvers can easily cause edema ...

AI Technical Summary

Problems solved by technology

However, these hypoglycemic drugs have various side effects

For example, biguanide compounds can easily cause lactic acidosis, sulfonylurea compounds can cause significant hypoglycemia, insulin resistance improving agents can easily cause edema and heart failure, and α-glucosidase inhibitors can cause abdominal pain, abdominal distension, diarrhea

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