Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicine composition, preparation method thereof and use thereof in preparing medicine for curing inflammatory enteropathy

A technology for inflammatory bowel disease and a composition is applied in the field of preparation of medicines for treating inflammatory bowel disease, and can solve the problems of not seeing inflammatory bowel disease and the like

Active Publication Date: 2010-08-18
YANTAI NEW ERA HEALTH IND
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, we have not seen any reports on the combination of the two for the treatment of inflammatory bowel disease

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicine composition, preparation method thereof and use thereof in preparing medicine for curing inflammatory enteropathy
  • Medicine composition, preparation method thereof and use thereof in preparing medicine for curing inflammatory enteropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1 kg of green tea leaves, crushed into powder, leached twice with 20 times the amount of 70% ethanol solution for 30 minutes each time, and the filtrate was collected to be the tea polyphenol-containing leaching solution. Most of the ethanol was recovered after the filtrate was evaporated and concentrated by a rotary evaporator. Add 500mL 3mol / L calcium chloride solution, and add 1mol / L sodium hydroxide solution under constant stirring to adjust the pH to about 7. After the solution was allowed to stand for a period of time, it was suction-filtered with a Buchner funnel. Filter cake is dissolved with 5mL / L hydrochloric acid solution, and the pH value of adjustment solution is about 4. The solution was heated to a slight boil and filtered while hot, and the filtrate was cooled and transferred to a separatory funnel. Ethyl acetate was added to extract 3 times to remove caffeine and further purify tea polyphenols. The extracts were combined, and the ester was recovered ...

Embodiment 2

[0021] Weigh 90g of pine pollen, 30g of green tea extract (prepared according to Example 1), mix evenly, pass through an 80 mesh sieve, add 200g of microcrystalline cellulose and 90g of starch as diluent to form a formulation, mix evenly, and spray 75% ethanol It is a soft material made of binder, granulated with a 24-mesh sieve, granulated after drying, mixed evenly, pressed into tablets, made into 1000 tablets, coated, and obtained. Each tablet contains 120 mg of a mixture of pine pollen and green tea extract.

Embodiment 3

[0023] Weigh 50 g of pine pollen, 50 g of green tea extract (prepared according to Example 1), mix evenly, pass through an 80-mesh sieve, suspend in 400 g of soybean oil, grind evenly through a colloid mill, and use 500 mg / grain as a feed liquid to suppress, Made into 1000 tablets, dried, shaped and packaged, each tablet contains 100 mg of the mixture of pine pollen and green tea extract.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a medicine composition containing pollen pini and green tea extract and use thereof in preparing medicine for curing inflammatory enteropathy. The invention further discloses a preparation method of green tea extract, specifically comprising the following steps: taking and grinding tea leaves into powder, adding a 10-30 folds amount of extraction solvent, heating for 10-60 minutes for extraction, filtering, recycling filtrate, depositing with calcium chloride, adjusting the pH, carrying out vacuum filtration, dissolving a filter cake with hydrochloric acid solution, and adjusting the pH value of the solution to be about 4. The solution is heated till slight boiling state and is filtered when still hot, and the filtrate is conveyed to a separating funnel after cooled. Acetic ether is added for extraction, and a rotatory evaporator is used for recycling acetic ether, and green tea extract is obtained after evaporation. The content of EGCG is 10%-90%, and preferably the content of EGCG is 30%-70%.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition, a preparation method thereof, and an application of the pharmaceutical composition in preparing medicine for treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBD) is a group of chronic intestinal inflammatory diseases of unknown etiology, including ulcerative colitis (UC) and Crohn's disease (CD). In recent years, the incidence of IBD at home and abroad is on the rise. Its etiology and pathogenesis are caused by many factors, that is, on the basis of genetic material, due to antigen stimulation and activation of the immune system in the body, various environmental factors interact. Chronic intestinal inflammation. At present, the exact etiology and pathogenesis are still not very clear, and the complexity of its pathogenesis has caused certain difficulties in clinical radical treatment. It is listed as one of the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61P1/00A61P1/04
Inventor 刘志河刘珂石丽花刘军锋王桐邵萌尹利端何克江许卉范华英
Owner YANTAI NEW ERA HEALTH IND
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com