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Molecular imprinting photonic crystal for detecting glucose

A photonic crystal and molecular imprinting technology, applied in the field of applied chemistry and clinical analysis and testing, can solve the problems of complex steps, intrusion into the human body, and high cost, and achieve the effect of convenient detection.

Inactive Publication Date: 2010-08-04
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a real-time and rapid glucose detection material and method to solve the problems of traditional methods such as high cost, complicated steps, and the need to invade the human body

Method used

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  • Molecular imprinting photonic crystal for detecting glucose

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example 1

[0020] The synthesis method of the molecularly imprinted photonic crystal for glucose detection of the present invention, the specific steps are as follows:

[0021] 1. Place the slide in a beaker filled with 100mL deionized water and wash it ultrasonically for 5 minutes. Take another 250mL beaker, add 30mL of 30% H 2 o 2 And 70mL mass fraction is the concentrated sulfuric acid of 98%. Gently put the ultrasonically washed glass slides into the prepared mixed solution, soak for 12 hours, and wash the slides that have been treated with hydrophilicity three times with deionized water. Blow dry the cleaned substrate for later use.

[0022] 2. Take 280-300nm PMMA colloidal beads, dilute them with deionized water to a mass fraction of 1%, ultrasonically disperse them for 0.5h, and pour them into a large petri dish; Insert the sheet into the above-mentioned PMMA colloidal bead solution to ensure that the substrate is perpendicular to the horizontal plane of the solution; let it s...

example 2

[0027] The synthesis method of the molecularly imprinted photonic crystal for glucose detection of the present invention, the specific steps are as follows:

[0028] 1. Place the slide in a beaker filled with 200mL deionized water and wash it ultrasonically for 5 minutes. Take another 250mL beaker, add 30mL of 30% H 2 o 2 And 70mL mass fraction is the concentrated sulfuric acid of 98%. Gently put the ultrasonically washed glass slides into the prepared mixed solution, soak for 15 hours, and wash the slides with hydrophilic treatment five times with deionized water. Blow dry the cleaned substrate for later use.

[0029] 2. Take 280-300nm PMMA colloidal beads, dilute them with deionized water to a mass fraction of 1%, ultrasonically disperse them for 1 hour, and then pour them into a large petri dish; put the hydrophilized substrate prepared in the first step Insert it into the above PMMA colloidal bead solution to ensure that the substrate is perpendicular to the horizontal...

example 3

[0034] The synthesis method of the molecularly imprinted photonic crystal for glucose detection of the present invention, the specific steps are as follows:

[0035] 1. Place the slide in a beaker filled with 120mL deionized water and wash it ultrasonically for 10 minutes. Take another 250mL beaker, add 30mL of 30% H 2 o 2 And 70mL mass fraction is the concentrated sulfuric acid of 98%. Gently put the ultrasonically washed glass slides into the prepared mixed solution, soak for 13 hours, and wash the slides with hydrophilic treatment 4 times with deionized water. Blow dry the cleaned substrate for later use.

[0036] 2. Take 280-300nm PMMA colloidal beads, dilute them with deionized water to a mass fraction of 1%, ultrasonically disperse them for 0.5h, and pour them into a large petri dish; Insert the sheet into the above-mentioned PMMA colloidal bead solution to ensure that the substrate is perpendicular to the horizontal plane of the solution; let it stand at 32°C and 60...

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Abstract

The invention relates to a molecular imprinting photonic crystal for detecting glucose, which belongs to the technical field of applied chemistry and clinical analysis test. A method comprises the following steps: firstly, inserting a substrate subjected to hydrophilic treatment into PMMA colloidal pellet solution, and self-assembling pellets on the substrate to obtain a three-dimensional photonic crystal template; secondly, dripping molecular imprinting pre-polymerization solution on the edge of the three-dimensional photonic crystal template, and thermally polymerizing the template; and finally, cleaning the glucose imprinting template to obtain a glucose molecular imprinting photonic crystal template. The molecular imprinting photonic crystal has specific glucose adsorption performance, enables direct observation of the change, and fulfills the aim of real-time, quick and convenient detection.

Description

technical field [0001] The invention relates to a molecularly imprinted photonic crystal for glucose detection and an application thereof, which belongs to the technical field of applied chemistry and clinical analysis and testing. Background technique [0002] Molecularly imprinted polymers (MIPs) are polymerized by adding functional monomers and cross-linking agents in the presence of imprinted molecules (template molecules). After the polymerization reaction, the imprinted molecule is eluted to form a molecular recognition site complementary to the imprinted molecule in terms of functional groups and three-dimensional structure on the polymer skeleton. It has been confirmed that the specific recognition ability of MIPs to imprinted molecules is comparable to that of enzymes and antibodies. Photonic crystals (PCs) are nonlinear optical gels with continuous and regular pore structures. Photonic crystals with inverse opal structure can be obtained by template self-assembly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02B6/122C08F220/54C08F220/18C08F2/44C08J9/26G01N21/25
Inventor 孟子晖段廷蕊刘烽王一飞薛飞
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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