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Medicine combination of levoamlodipine or medicinal salt of levoamlodipine and auricularia auricula polysaccharide, and application thereof

A technology of levamlodipine and black fungus polysaccharides, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., can solve the problems that there are no articles on the combined use of levamlodipine and black fungus polysaccharides, Achieve the effect of less single drug dosage, good synergistic effect, and reduce adverse reactions

Inactive Publication Date: 2012-11-07
SHIHUIDA PHARMA GRP (JILIN) LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, no articles or patents on the combined use of levamlodipine and black fungus polysaccharides have been found

Method used

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  • Medicine combination of levoamlodipine or medicinal salt of levoamlodipine and auricularia auricula polysaccharide, and application thereof
  • Medicine combination of levoamlodipine or medicinal salt of levoamlodipine and auricularia auricula polysaccharide, and application thereof
  • Medicine combination of levoamlodipine or medicinal salt of levoamlodipine and auricularia auricula polysaccharide, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0022] Formulate the pharmaceutical composition as follows:

[0023] components

Example 1

Example 2

Example 3

Example 4

Black fungus polysaccharide (g)

50

100

150

200

Levoamlodipine besylate (g)

(by weight of levamlodipine)

2.5

2.5

2.5

2.5

Microcrystalline Cellulose (g)

30

40

60

80

Pregelatinized starch (g)

27.5

13.5

36.5

59.5

[0024] Lactose (g)

30

30

30

30

Sodium hydroxymethyl starch (g)

9

12

18

24

Magnesium stearate (g)

1

2

3

4

95% ethanol

Appropriate amount

Appropriate amount

Appropriate amount

Appropriate amount

Co-made (pieces)

1000

1000

1000

1000

[0025] Preparation method: Put levamlodipine besylate, black fungus polysaccharide, microcrystalline ce...

Embodiment 5

[0029] The therapeutic effect of the pharmaceutical composition of the present invention on mixed hypertension and hyperlipidemia is illustrated by the following animal pharmacodynamics examples.

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PUM

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Abstract

The invention relates to a medicine combination of levoamlodipine or medicinal salt of the levoamlodipine and auricularia auricula polysaccharide, and the application thereof. Active components of the medicine combination include the levoamlodipine or the medicinal salt of the levoamlodipine and the auricularia auricula polysaccharide. The medicine combination of the invention is applicable to treating mixed hypertension and hyperlipidemia.

Description

technical field [0001] The invention relates to a composition comprising levamlodipine or a pharmaceutically acceptable salt thereof and black fungus polysaccharide, and the application of the composition in the preparation of medicines for treating mixed hypertension and hyperlipidemia. technical background [0002] In recent years, with the continuous improvement of people's living standards in our country, changes in dietary structure, increase in life pressure, and increase in the elderly population, the incidence of hypertension and hyperlipidemia has a tendency to gradually increase. Hypertension and hyperlipidemia can lead to atherosclerosis, angina pectoris, myocardial infarction, cerebral infarction, kidney damage and other heart, cerebrovascular and vascular diseases, causing serious consequences. The occurrence of the disease is of great significance, and a monotherapy that can treat both diseases at the same time can improve patient compliance. [0003] Levoamlo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K31/4422A61P9/12A61P3/06
Inventor 杨彦玲薛传校张喜田李环宋森涛
Owner SHIHUIDA PHARMA GRP (JILIN) LTD
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