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Method for preparing selenic acid arginine and application of selenic acid arginine

A technology of arginine selenate and arginine, which is applied in the directions of food preparation, application, pharmaceutical formulation, etc., can solve the problem of narrow safe dosage range of selenium, and achieve the effects of low toxicity and high absorption rate.

Inactive Publication Date: 2010-07-07
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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AI Technical Summary

Problems solved by technology

[0002] Selenium is an essential trace element for humans and animals. It can protect the structure and function of cell membranes, enhance the body's immunity, and play an important role in maintaining biological functions and preventing diseases. However, the safe dosage range of selenium is very narrow, so low-toxic selenium compounds The development and research of the

Method used

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  • Method for preparing selenic acid arginine and application of selenic acid arginine
  • Method for preparing selenic acid arginine and application of selenic acid arginine
  • Method for preparing selenic acid arginine and application of selenic acid arginine

Examples

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Embodiment 1

[0010] Embodiment 1: the preparation of arginine selenate

[0011] 10g arginine, 5g selenium dioxide, H 2 o 2 Add it to 50ml of aqueous solution, stir in vacuum and low temperature for 5h, then add 100ml of ethanol to precipitate, and filter. The precipitate was washed successively with 20ml x 3 ethanol, and the precipitate was vacuum freeze-dried to obtain the arginine selenate product with a selenium content of 213.7 mg / g.

Embodiment 2

[0012] Example 2: Alcoholic liver injury model in mice tested that arginine selenate can effectively maintain the liver

[0013] In this experiment, the mouse model of alcoholic liver injury was replicated by intragastric administration. The results showed that arginine selenate had obvious inhibitory effect on alcohol-induced hepatocyte morphological changes, steatosis and liver fibrosis. Arginine selenate significantly inhibited the increase of serum hyaluronic acid and the increase of liver collagen synthesis in alcoholic liver injury, and the levels of antioxidants such as GSH-Px, SOD, and GSH in the liver were significantly higher than those in the alcohol group. Both the degree of lipid peroxidation and the degree of protein oxidation were significantly lower than those in the alcohol group. Studies on lipid metabolism have shown that arginine selenate can effectively reduce the alcohol-induced increase in serum cholesterol and maintain a high level of high-density lipo...

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Abstract

The invention discloses a method for preparing selenic acid arginine and application of the selenic acid arginine. A novel organic selenium source is prepared by using arginine and SeO2 as raw materials and using a chemical synthesis method to introduce selenic acid radicals into arginine molecules. The structure (shown in an attached figure 1) of the selenic acid arginine is analyzed and determined by using the techniques of a high-efficiency liquid chromatography, an infrared spectrum, a nuclear magnetic resonance spectrum and the like. The selenic acid arginine has low toxicity, is easy to absorb, and can serve as a novel selenium-supplementing preparation used in the fields of medicaments, health products, cosmetics and the like.

Description

technical field [0001] The invention relates to a preparation method and application of a new selenium compound, ie arginine selenate. Background technique [0002] Selenium is an essential trace element for humans and animals. It can protect the structure and function of cell membranes, enhance the body's immunity, and play an important role in maintaining biological functions and preventing diseases. However, the safe dosage range of selenium is very narrow, so low-toxic selenium compounds The development and research of it has attracted extensive attention. More and more evidence shows that organic selenium is obviously superior to inorganic selenium in terms of safety performance and disease prevention, and has the advantages of low toxicity, high absorption rate and good effect. Contents of the invention [0003] The purpose of the present invention is to prepare a new type of selenium compound, that is, arginine selenate, which can be used as a new type of selenium ...

Claims

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Application Information

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IPC IPC(8): C07C391/00A61K31/21A23L1/29A61K8/58A61P3/02A61P35/00A61P39/06A61P37/00A61P1/16A61Q19/08A23L33/00
Inventor 刘安军朱振元
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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