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Pharmaceutical composition for malignancy treatment and application thereof

A technology for malignant tumor and composition, applied in the field of biomedicine, can solve the problems of complex components of traditional Chinese medicine, and achieve the effect of reasonable combination formula and convenient use

Inactive Publication Date: 2011-08-24
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

my country's traditional Chinese medicine resources are precious cultural heritage, which provides a rich material basis for the screening of anti-tumor drugs. However, the components of traditional Chinese medicine are complex. How to effectively use the anti-cancer components and provide scientific research data, from which to screen high-efficiency and low-efficiency drugs The use of monomeric compounds that are toxic, have a wide range of targets, and have significant reversal effects for anti-tumor therapy has become the focus of current cancer research.

Method used

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  • Pharmaceutical composition for malignancy treatment and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0066] Experimental example 1: Effects of curcumin and tetrandrine alone and in combination on glioma cell D37

[0067] The inhibitory effect of Cur and Tet on the growth of glioma cell D37 was detected by the trypan blue dyeing method. The experiments were divided into control group, curcumin group (Circumin), Tetrandrine group Tetrandrine and curcumin group (Cur / Tet), using different concentrations of tetrandrine and curcumin alone or mixed to act on human glioma cells D37 tumor cells, after 5 days of drug treatment, detect by trypan blue dyeing method Cytotoxicity of anticancer drugs. The results showed that different concentrations of Cur and Tet alone could inhibit the growth of tumor cells to a certain extent, and the effect was concentration-dependent. As shown in Table 1, the cell growth inhibition rates of 2.5 μM, 5 μM and 15 μM Cur on glioma cell D37 were 3.4%, 8.4% and 21.5%, and 2.5 μM, 5 μM and 15 μM Tet on glioma cell The cell growth inhibition rates of D37 wer...

experiment example 2

[0070] Experimental example 2: Effects of curcumin and tetrandrine alone and in combination on human gastric cancer cell line HS746T

[0071] The inhibitory effects of Cur and Tet on the growth of gastric cancer cell line HS746T were detected by trypan blue dyeing method. In the curcumin group (Cur / Tet), different concentrations of tetrandrine and curcumin were used alone or in combination to act on human gastric cancer cell HS746T tumor cells. After 5 days of drug treatment, the cytotoxicity of antineoplastic drugs was detected by trypan blue exclusion method effect. The results showed that different concentrations of Cur and Tet alone could inhibit the growth of tumor cells to a certain extent, and the effect was concentration-dependent. As shown in Table 2, the cell growth inhibition rates of 3 μM, 5 μM and 15 μM Cur on human gastric cancer cell HS746T were 5.3%, 7.8% and 18.8%, respectively, and the cell growth inhibition rates of 3 μM, 5 μM and 15 μM Tet on gastric cance...

experiment example 3

[0074] Experimental example 3: Effects of curcumin and tetrandrine alone and in combination on human liver cancer cells HepG2

[0075] The inhibitory effect of Cur and Tet on the growth of human liver cancer cells HepG2 was detected by trypan blue staining method. The experiments were divided into control group, curcumin group (Circumin), Tetrandrine group and curcumin group (Cur / Tet), using different concentrations of tetrandrine and curcumin alone or mixed to act on human liver cancer cells HepG2 tumor cells, after 5 days of drug treatment, the cells of anti-tumor drugs were detected by trypan blue exclusion method toxic effect. The results showed that different concentrations of Cur and Tet alone could inhibit the growth of tumor cells to a certain extent, and the effect was concentration-dependent. As shown in Table 3, the cell growth inhibition rates of 3 μM, 5 μM and 15 μM Cur on human liver cancer cell HepG2 were 2.5%, 4.9% and 12.7%, respectively, and the cell growth ...

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Abstract

The invention discloses a pharmaceutical composite for malignancy treatment and an application thereof. The pharmaceutical composite is proportionally prepared by curcumin and tetrandrine. The medicine prepared thereby comprises a preparation-allowed pharmaceutical excipient or carrier. The important point is that the synergistic effect of curcumin and tetrandrine on malignancy treatment is discovered. In particular, the pharmaceutical composite is applicable to glioma, lung cancer, liver cancer, gastric cancer, intestinal cancer, breast cancer, cervical cancer, pancreatic cancer and leukemia. The medicine has reasonable formulation, definite effective ingredients and obvious antitumor effect, and can reduce the clinical administration of the existing anticancer drugs, improve anticancer effect, reduce toxic side effect, and has application prospect of preparing antitumor drugs.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and more specifically relates to a pharmaceutical composition for treating malignant tumors, and also relates to the use of the medicine. The pharmaceutical composition is especially suitable for anti-glioma, lung cancer, liver cancer, gastric cancer, Intestinal cancer, breast cancer, cervical cancer, pancreatic cancer, leukemia, etc. Background technique [0002] Malignant tumor has always been one of the killers that seriously threaten human survival and health. It and cardiovascular disease are the first two causes of death caused by diseases, and have become two major difficulties in medicine. Common malignant tumors in my country include: lung cancer, gastric cancer, esophageal cancer, colon cancer, liver cancer, cervical cancer, breast cancer, leukemia, malignant lymphoma, nasopharyngeal cancer and other ten tumors. Among them, lung cancer, gastric cancer, esophageal cancer, liver canc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4748A61K31/12A61P35/00
Inventor 李文鑫毛歆余春荣李文化
Owner WUHAN UNIV
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