Animal model for showing rabbit temporomandibular joint intracapsular synechia and building method thereof

A technique of temporomandibular joint and animal model, which is applied to the animal model of intracapsular adhesion of the temporomandibular joint in rabbits and the field of its establishment.

Inactive Publication Date: 2010-07-07
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

In order to study the adaptive reconstruction of the double-plate area of ​​the joint, Gu Zhiyuan et al. have improved the establishment method of the TMJID animal model, using double-strand rubber bands to continuously pull the protruding part of the joint disc, but did not study the IA

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  • Animal model for showing rabbit temporomandibular joint intracapsular synechia and building method thereof
  • Animal model for showing rabbit temporomandibular joint intracapsular synechia and building method thereof
  • Animal model for showing rabbit temporomandibular joint intracapsular synechia and building method thereof

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Embodiment 1

[0031] 1 Materials and methods

[0032] 1.1 Materials

[0033] 1.1.1 Experimental animals and grouping 16 healthy adult New Zealand big-eared white rabbits were provided by the Experimental Animal Center of Shanghai Jiao Tong University School of Medicine, and were adaptively raised in the animal room of Shanghai Ninth People's Hospital for 2 weeks before the experiment. The inclusion criteria for experimental animals are: 6 months old, weighing 2.5-3kg, without missing teeth, abnormal occlusion, good nutrition, without systemic diseases, and agile. The experimental animals were randomly divided into 4 groups, 4 animals in each group; the right joint was used as the experimental side, and the left side was the control side; MRI and endoscopic observations were carried out at 1, 2, 4 and 8 weeks after operation, and the articular discs were detected The degree of displacement and the formation of joint IA were determined, and then the animals were sacrificed to obtain specimen...

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Abstract

The invention relates to an animal model for showing rabbit temporomandibular joint intracapsular synechia. The animal model can be built according to the following method that the articular disc of a white rabbit generally anaesthetized is drawn forward by a rubber band to be transferred, then nuclear magnetic resonance and endoscope are used to check if the model is successfully built up. The invention also provides a building method for the rabbit temporomandibular joint intracapsular synechia. The invention can provide a reliable animal model for the research of the forming mechanisms of temporomandibular joint intracapsular synechia and temporomandibular joint osteoarthropathy and also for the medicine research for preventing and curing the temporomandibular joint intracapsular synechia and the temporomandibular joint osteoarthropathy.

Description

【Technical field】 [0001] The invention relates to an animal model, in particular to a rabbit temporomandibular joint intracapsular adhesion animal model and its establishment method. 【Background technique】 [0002] Temporomandibular joint (TMJ) structural disorder (internal derangement, ID) is a common and frequently-occurring disease. According to statistics, the incidence rate in the population is as high as 28% to 88%. The main clinical manifestations are pain, limited mouth opening, joint noise and Mandibular dysfunction, etc., seriously affect the patient's chewing, language and other functions, and even have a great impact on the patient's psychology. Many scholars explored the tissue changes after TMJ ID by establishing animal models of TMJ ID, but less attention was paid to intra-articular adhesion (IA), the most common comorbidity as high as 55%-93%. [0003] Since Tallents et al. reported the method of establishing the TMJADD animal model in 1990, some scholars ha...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B19/00G09B23/28A61B90/00
Inventor 张善勇杨驰刘秀明魏魁杰陈敏洁蔡协艺
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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