Hair-growing agent composition

A technology of composition and hair growth agent, which is applied in the direction of drug combination, active ingredients of heterocyclic compounds, hair care, etc., can solve the problems of not being able to obtain significant improvement effects, and achieve excellent anti-hair loss effects

Inactive Publication Date: 2010-06-30
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The 6-benzylaminopurine is a compound known to have a hair growth effect (refer to Patent Document 2), and the effectiveness of a hair growth agent mixed with 6-benzylaminopurine has been tested in women with alopecia. In the confirmation test, a slight improvement effect can be seen, but a significant improvement effect has not yet been obtained (refer to Non-Patent Document 3)

Method used

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  • Hair-growing agent composition
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0086] Hereinafter, examples of the present invention will be described, but not limited by these examples.

[0087]

[0088] The method for measuring the proliferative activity of epidermal keratinocytes was performed as follows.

[0089] As normal human epidermal keratinocytes, a 24-year-old woman's primary culture frozen product (manufactured by Cascade Biologics, NHEK (B)) was used. Also, Humedia KG2 (manufactured by Kurabo Industries, Ltd.) was used as the medium. 4400 cells / well were seeded on a 24-well plate (manufactured by Sumitomo Backlight Co., Ltd.), and cultured at 37°C under 5% carbon dioxide gas and saturated water vapor. After culturing for 24 hours, the culture solution was aspirated, fresh Humedia KG2 was added, and evaluation substances were added, and cultured for another 48 hours. After the cultivation, Alamar Blue (manufactured by Invitrogen) was added to a concentration of 10%, and the fluorescence (excitation at 544 nm, measurement at 590 nm) was me...

Embodiment 1～9 and comparative example 1～5

[0117] Preparation of hair tonic composition

[0118] According to the composition shown in the following Table 1, the hair growth agent composition was prepared by the usual method. In addition, the compounding ratio unit is mass %, and a total amount is 100 mass %.

[0119] About each obtained hair growth agent composition, the clinical test result about the therapeutic effect of androgenetic alopecia was performed as shown below. The results are shown in Table 1.

[0120]

[0121] Taking 104 female volunteers with diffuse alopecia as subjects, there were 13 groups in total for the test drug group and the control group, and 8 people in each group were randomly divided into groups.

[0122] The test is to apply an appropriate amount from the front of the head to the top of the head twice a day, morning and evening. The investment period is 4 months.

[0123] At the end of the test (4 months), the hair was shampooed, and the bamboo basket was covered with 2 layers of non...

Embodiment 1

[0157] -Hair growth agent-

[0158] ·Flavonosterone S E * : 0.1% by mass...(A) component

[0159] ・6-Benzylaminopurine: 0.5% by mass...(B) component

[0160] Extraction of Coleus Forskohlii root Purified extract: 3.0% by mass

[0161] ・Coco fatty acid sorbitan: 1.0% by mass

[0162] ・Sucrose myristate: 0.5% by mass

[0163] ・Lauryl dimethylaminoacetate betaine: 0.5% by mass

[0164] ・Concentrated glycerin: 0.8% by mass

[0165] ・Decaglycerol myristate: 0.3% by mass

[0166] ・Biotin: 0.002% by mass

[0167] ・Succinic acid: 0.3% by mass

[0168] DL-α-tocopherol acetate: 0.1% by mass

[0169] · Fragrance: 0.5% by mass

[0170] ・95% ethanol: 50% by mass

[0171] ·Refined water: balance

[0172] Flavonosterone SE is a soybean extract manufactured by Ichimaru Farcos Co., Ltd., and the extract contains 0.1% by mass of daidzein and 0.02% by mass of genistin.

[0173] Molar ratio [(A) component: (B) component] = 1: 7947 (the molar ratio is the value rounded to one digit af...

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Abstract

The invention provides a hair-growing agent composition, which is capable of treating exiguous human hair, calvities occurring in females due to lowering of the estrogen concentration along with the aging by using soybean isoflavones aglycone and 6-benzyl amino purine at the same time, and has great calvities prevention effect while having hair-growing effect. The invention provides a hair-growing agent composition containing soybean isoflavones aglycone and 6-benzyl amino purine. An ideal condition is that the soybean isoflavones aglycone is any one from the daidzin, genistin, and the mol ratio between soybean isoflavones aglycone (A) and 6-benzyl amino purine is 1:1000000 - 1000:1 or the like.

Description

technical field [0001] The present invention relates to a hair growth agent composition which has an excellent effect of promoting the proliferation of epidermal keratinocytes and promoting the expression of BMP-2 gene. Background technique [0002] It has long been desired to provide an effective hair growth agent for hair problems caused by the drastic reduction of estrogen in women. Soybean isoflavones are known as compounds having female estrogen-like actions, and among them, malonyl soy isoflavone glycosides are known to have an action of proliferating epidermal keratinocytes (refer to Patent Document 1). However, the above-mentioned malonyl soybean isoflavone glycosides are easily decomposed by heat, and there is a problem of malonyl hydrolysis during long-term storage. [0003] On the other hand, BMP-2 is known as a reduced protein in the human scalp of alopecia (refer to Non-Patent Document 1). Therefore, as a compound that promotes BMP-2 production, the present ap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/52A61P17/14A61K8/60A61K8/49A61Q7/00
CPCA61K8/49
Inventor 山田裕子小八木友子永原恭生
Owner LION CORP
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