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Application of hyperin for treating herpes zoster, burn, scald, traumatic infection and tumors

A technology of hyperin and herpes zoster, which is applied in the field of biomedicine and can solve problems such as the application of hyperoside that has not yet been seen

Inactive Publication Date: 2010-06-23
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, there is no application of hyperoside for herpes zoster, burns and scalds, trauma infection drugs and carbuncle swelling drugs.

Method used

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  • Application of hyperin for treating herpes zoster, burn, scald, traumatic infection and tumors
  • Application of hyperin for treating herpes zoster, burn, scald, traumatic infection and tumors
  • Application of hyperin for treating herpes zoster, burn, scald, traumatic infection and tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Pharmacodynamic experiment

[0017] (1) Therapeutic effect of hypericin ointment on burns in mice

[0018] 1. Experimental method:

[0019] Select 30 healthy male Kunming mice with a weight of 25-30g. 24 hours before the model is established, the back of the mice is sheared, and then the prepared Na 2 S The back of the mouse was depilated, and the depilation area was 2.5×2.5 cm. 24 hours after hair removal, the mouse model of scald was established with the YLS-Q5 portable temperature-controlled scald instrument. The diameter of the burn instrument is 16mm, the surface temperature is 100°C, and the pressure is 500g. During modeling, the surface of the scalding instrument was directly contacted with the hair removal area on the back of the mouse for 4 seconds. The skin tissue on the wound surface was pale, and the wound surface was uniformly injured. The wound edge formed a white boundary line around it, which could be clearly demarcated from the surrounding ...

Embodiment 2

[0045] Example 2 Clinical observation of 45 cases of herpes zoster patients treated with hypericin gel

[0046] 1 Materials and methods

[0047] 1.1 Case selection

[0048] There were 45 cases in the treatment group, including 26 males and 19 females, aged 18 to 61; the control group included 39 cases, and there was no significant difference between the selected cases and the treatment group (P>0.05).

[0049] 1.2 Treatment methods and drug dosage

[0050]In the treatment group, in addition to conventional antiviral drugs for the treatment of herpes zoster (oral ribavirin, injection of acyclovir, polyinosin, etc.), B vitamins (vitamin B1, B12, etc.), at the same time, local administration of gold wire Atherin gel was applied externally, 4 times a day, and the course of treatment was 1-2 weeks; the control group did not add hyperin gel, and the rest of the treatment was the same as that of the treatment group.

[0051] 1.3 Efficacy Judgment Criteria

[0052] After 1 week of...

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Abstract

The invention discloses a new purpose of hyperin, in particular to the purpose of the hyperin in preparation of medicine for treating herpes zoster, burn, scald, traumatic infection and tumors. Experimental studies discover the following: with the pharmacological effects of diminishing inflammation, easing pains, promoting healing and resisting virus, the hyperin can be applied in the preparation of the medicine for treating herpes zoster, burn, scald, traumatic infection and tumors.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new medicinal use of hyperoside, in particular to the use of hyperoside in preparing medicines for treating herpes zoster, burns and scalds, trauma infections and carbuncle swollen medicines. Background technique [0002] Hyperin (Hyperin, Hyperoside, Hyp), also known as quercetin-3-O-13-D galactopyranoside, belongs to flavonol glycosides. The aglycone is quercetin, the glycosyl is galactopyranosyl, and the 3-position O atom of quercetin is connected to the glycosyl by a β-glycosidic bond. It is widely found in various plants, such as the fruits and whole plants of Hypericaceae, Rosaceae, Platycodonaceae, Lamiaceae, Berberaceae, Rhododendron, and Sunflower. Its chemical structure is attached to the manual figure 1 , the manual is attached figure 1 For the chemical structure of hypericin. [0003] Modern pharmacological studies have shown that hyperoside has a variety of pharmacologi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P31/12A61P17/02A61P17/00
Inventor 张玲凌沛学尚立霞吴永霞曲延伟
Owner 凌沛学
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