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Magnesium compositions and uses thereof

A composition and technology of magnesium compounds, applied in the field of oral dosage forms containing magnesium, in the field of preparation of food supplements, can solve the problems of insolubility, difficult delivery and the like

Active Publication Date: 2010-06-16
NEUROCENTRIA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these compounds have the ability to increase magnesium levels, they are largely insoluble in the gastrointestinal tract and, therefore, cannot be easily delivered to the gastrointestinal system without side effects

Method used

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  • Magnesium compositions and uses thereof
  • Magnesium compositions and uses thereof
  • Magnesium compositions and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0165] The preparation of the pharmaceutical compositions of the present invention is carried out according to generally accepted procedures for the manufacture of pharmaceutical formulations. See, eg, Remington's Pharmaceutical Sciences 18th Edition (1990), edited by E.W. Martin, Mack Publishing Co., PA. Depending on the intended use and mode of administration, it may be necessary to further manipulate the magnesium-counter ion compound in the preparation of the pharmaceutical composition. Proper processing may include admixing with suitable nontoxic and noninterfering ingredients, sterilization, subdividing into dosage units and packaging in a delivery device.

[0166] Pharmaceutical compositions for buccal, intranasal or topical administration may be presented in solid, semi-solid or liquid form, including tablets, capsules, powders, liquids and suspensions. Compositions for injection can be presented as liquid solutions or suspensions, as emulsions, or as solid forms suit...

Embodiment 1

[0202] Embodiment 1: the preparation of magnesium threonate

[0203] According to the procedure described by Wei et al., J.Org.Chem.50, 3462-3467 (1985), first, 264 g (1.5 moles) of vitamin C, 300 g (3 moles) of calcium carbonate and 600 mL of 30 volume % H 2 o 2 Preparation of calcium threonate. The prepared calcium threonate was redissolved in ~3 L of water at ~90°C. The resulting solution was cooled to ~50°C and then poured into a 3 inch diameter column filled with ~3 L of clean Amberlite IR-120 strong acid resin while the column was continuously eluted with water. Fractions containing threonic acid having a pH below about 4.5 were collected. The threonic acid fractions (~7 to ~8 L) were combined and stirred at ~50 to ~60°C. Add Mg(OH) to threonic acid in small amounts 2 powder until the pH reaches 7. The resulting solution was filtered and concentrated by rotary evaporation at ~50 °C to a final volume of ~700 to ~800 mL. The concentrated solution was cooled to roo...

Embodiment 2

[0204] Embodiment 2: taste comparison

[0205] In a double-blind test, each of 16 volunteers, 9 men and 7 women, aged 20-22 years, was given 1 glass containing 50% by weight of magnesium gluconate, 25% by weight of magnesium lactate and 25% by weight of magnesium lactate. % of the composition of skim milk of a mixture of magnesium citrate (composition 1), which has a total concentration of elemental magnesium associated with the mixture of 50 mM; and 1 glass of the composition of skim milk and magnesium gluconate (composition 2 ) with a total concentration of elemental magnesium related to magnesium gluconate at a concentration of 50 mM. Each volunteer was asked to taste both compositions and state his or her preference for one or the other or neither. like figure 1 As shown, most subjects (87.5%) preferred Composition 1 and a minority (12.5%) preferred Composition 2.

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Abstract

A composition for administration to a subject, such as oral administration to a subject, for example, has been provided. Such a composition may comprise at least one magnesium-counter ion compound. A magnesium- counter ion composition described herein may be useful for any of a variety of applications provided herein, such as maintaining, enhancing, and / or improving health, nutrition, and / or another condition of a subject, and / or cognitive, learning, and / or memory function. A magnesium-counter ion composition provided herein may be useful for administration to a subject presenting magnesium deficiency, mild cognitive impairment, Alzheimer's disease, attention deficit hyperactivity disorder, ALS, Parkinson's disease, diabetes, migraine, anxiety disorder, mood disorder, and / or hypertension. A kit, method, and other associated technology are also provided.

Description

Background of the invention [0001] Magnesium is present in the human body and plays a variety of roles. At the molecular level, magnesium is a cofactor for more than 300 enzymes responsible for some of the most important biological activities in mammals, including humans. In living cells, magnesium is involved in the homeostasis of other minerals such as sodium, potassium and calcium, and in the formation, transfer, storage and utilization of adenosine triphosphate (ATP), the main source of energy in living cells. In the human body, magnesium is involved in the maintenance of normal muscle and nerve function, heart rhythm, bone strength and immune system health. Magnesium is also involved in regulating blood sugar levels and promoting normal blood pressure. [0002] Magnesium has been reported to play a role in the regulation of synaptic plasticity (Slutsky et al., Neuron, 44, 835-849 (2004)), which is thought to be involved in early developmental processes. The organizatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/225A61P25/28
CPCA23V2002/00A61K35/20A61K31/198A61K31/225A61K33/06A23L1/304A23L33/16A61K31/185A61K31/19A61K31/191A61K31/194A61K31/375A61K31/4015A61K2300/00A23V2200/322A23V2200/30A23V2200/302A23V2250/161A61P25/00A61P25/14A61P25/16A61P25/18A61P25/22A61P25/24A61P25/28A61P3/00A61P3/02A61P3/10A61P9/12A23L33/15A61K8/19A61K9/0019A61K9/0053A61K9/0073A61K9/20A61K9/48A61K33/14A61K45/06A61Q15/00
Inventor 刘国松伯恩哈德·K·迈斯特周行毛飞
Owner NEUROCENTRIA INC
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