Radix notoginseng extract and preparation thereof

Abstract

The invention provides a radix notoginseng extract which contains 5-10% of notoginsenoside R1, 25-36% of ginsenoside Rg1, 2.5-5% of ginsenoside Re, 30-39% of ginsenoside Rb1, 5-10% of ginsenoside Rd and at least 2% of ginsenoside Rf, ginsenoside Rh1, ginsenoside Rc, ginsenoside Rb2 and ginsenoside Rg3, wherein the ginsenoside R1, the ginsenoside Rg1, the ginsenoside Re, the ginsenoside Rb1 and the ginsenoside Rd account for 75-95% of the total weight. The invention also provides a preparation method of the radix notoginseng extract. The radix notoginseng extract prepared by the method has little impurities, the purity of the component of total saponin is higher, and especially, the components of the ginsenoside Rf, the ginsenoside Rh1, the ginsenoside Rc, the ginsenoside Rb2, the ginsenoside Rg3 and the like with very low content are purified. The medicinal preparation prepared by the radix notoginseng extract has better curative effect and higher safety.

Description

technical field [0001] The invention relates to a notoginseng extract and its preparation, belonging to the technical field of medicine. Background technique [0002] In the 1930s, Chinese scholars began to study the extract of Panax notoginseng, but limited by the conditions at that time, the research progressed slowly. After the 1970s, with the wide application of modern separation methods and detection instruments, the research on the chemical components of Panax notoginseng extracts has made significant progress. The chemical components of Panax notoginseng include saponins, volatile oils, amino acids (notoginseng), polyacetylenic alcohols, flavonoids, sterols, sugars, organic acids, cyclic dipeptides, ginseng lactams, inorganics, etc. But its main active ingredient is Panax notoginseng saponins, including Panax notoginsenoside R 1 , Ginsenoside Rg 1 , Ginsenoside Rb 1 etc., the content accounts for about 10-12% of Radix Notoginseng. [0003] The common extraction m...

AI Technical Summary

Problems solved by technology

[0002] In the 1930s, Chinese scholars began to study the extract of Panax notoginseng. Due to the constraints of the conditions at that time, the research progress was slow.

[0003] The common extraction methods of Panax notoginseng are water decoction, alcohol reflux and ultrasonic extraction, but since Panax notoginseng also contains a large amount of starch, when extracting the total saponins of Panax notoginseng, it is generally not suitable to use water or low-concentration ethanol extraction to avoid gelatinization; Although the content of total saponins of Panax notoginseng obtained by ultrasonic extraction is relatively high, considering that ultrasonic extraction is not suitable for large-scale application in technology, the alcohol reflux method is still the best method for extracting total saponins of Panax notoginseng

[0004] In existing literature reports, 60% or 80% ethanol is often used for reflux extraction, but the selection of process parameters in the extraction process is different, which will directly lead to great differences in the types and contents of the active ingredients of Panax notoginseng saponins